哮喘儿童细胞免疫相关因子的研究

A study on Immunologic Cytokine in Children with Asthma

目的探讨小儿哮喘的免疫功能状态。方法选取88例哮喘患儿进行CD4、CD8、CD4/CD8、IgE、EOS、eNO、红细胞CD35、红白细胞CD59的检测,并与健康同龄儿进行比较。结果 CD4、CD8数值哮喘组均低于对照组(P均<0.05),IgE、eNO数值哮喘组明显高于对照组(P均<0.01),EOS数值哮喘组高于对照组(P均<0.05);红细胞CD35、CD59、白细胞CD59与对照组相比差异无统计学意义(P均>0.05),红细胞自然免疫粘附肿瘤花环率(NTRR)较对照组(24.02±4.86)明显降低,差异有显著统计学意义(P<0.01)。结论哮喘儿童存在免疫功能紊乱,在治疗上应进行免疫功能调整。

Objective To investigate the change of immunologic Cytokine in children with asthma. Methods CD4,CD8,CD4/CD8,IgE, EOS,eNO,CD35 and CD59 of Erythrocyte,CD59 of in 88 cases with asthma. The resμLts were compared with healthy children of the same age. Results CD4 and CD8 were lower in asthma group were lower than that in control group（P〈0.05）. IgE and eNO were obviously higher than that in control group（P〈0.01）. EOS were higher than that in control group（P〈0.05）. Compared with control group, the quantity of CD35 and CD59 had no obvious changes（P〉0.05）and NTRR obviously fell in observation group（P〈0.01）. Conclusion There was immune functional defect in children with asthma. Adjusting the immune function shoμLd be emphasized in treatment to children with asthma.