孕酮及PAPP-A在复发性自然流产预测中的表达及意义

Expressions and significances of progesterone and PAPP-A in predicting recurrent spontaneous abortion

目的:探讨孕酮及妊娠相关血浆蛋白-A(PAPP-A)在复发性自然流产(recurrent spontaneous abortions,RSA)预测中的表达及其临床意义。方法:选择42例不明原因复发流产史的妇女为治疗组和30例有生育史的正常妇女为对照组,检测两组孕6周、9周、11周血清中孕酮及PAPP-A的表达。结果:两组6周、9周、11周孕酮水平比较,差异具有统计学意义(P<0.05)。血清孕酮及PAPP-A值95%可信区间的高限分别为18.7 ng/m l和21.7IU/L,两组阳性率分别为90.5%(38/42),95.2%(40/42)。孕酮及PAPP-A评价率与对照组比较,差异有统计学意义(P<0.005)。结论:RSA孕妇妊娠过程中,孕酮及PAPP-A均为高表达。孕酮<18.7 ng/m l和PAPP-A<21.7 IU/L则代表有可能发生RSA。

Objective： To explore the expressions and significances of progesterone and pregnancy - associated plasma protein - A （ PAPP - A） in predicting recurrent spontaneous abortion （ RSA ） . Methods： Forty - two women with history of RSA and thirty normal women with childbearing history were selected as treatment group and control group respectively; the expressions of progesterone and PAPP - A in serum at 6, 9, and 11 gestational weeks in the two groups were detected. Results： There were statistically significant differences in the serum levels of progesterone at 6, 9, and 11 gestational weeks between the two groups （ P 〈 0. 05 ） ; the high limits of 95% credibility inter- vals of serum progesterone and PAPP - A were 18.7 ng/ml and 21.7 IU/L, respectively; the positive rates in the two groups were 90. 5 % （38/42） and 95.2% （40/42） , respectively; there was statistically significant difference in the evaluation rates of progesterone and PAPP - A between the two groups （ P 〈 0. 005 ） . Conclusion： The expression levels of progesterone and PAPP - A are high in pregnant women with RSA ; progesterone level 〈 18.7 ng/ml and PAPP - A level 〈 21.7 IU/L probably indicate RSA.