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中药敷脐联合托烷司琼防治含顺铂方案所致呕吐、食欲减退随机平行对照研究 被引量:4

The Parallel Controlled Study of Tropisetron combined with Herbs used Externally in Treatment of Emesis and Anorexia Caused by Cisplatin-based Chemotherapy
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摘要 [目的]观察中药敷脐联合托烷司琼防治含顺铂方案所致呕吐、食欲减退疗效。[方法]使用随机平行对照方法,将63例住院患者按随机数字表随机分为两组。对照组在化疗开始至化疗结束1个周期内每天化疗前半小时静脉予1次5mg托烷司琼和5mg的地塞米松注射液。化疗第1d开始前0.5h给予中药敷脐,每天24h持续敷药,直至化疗结束。化疗方法同对照组。观察1个周期化疗过程中前5d的呕吐、食欲减退情况和化疗结束24~48h的呕吐情况。[结果]治疗组出现恶心的程度偏轻且恶心患者例数显著偏少,d3、d5均P〈0.05,d4的P〈0.01;治疗组较对照组出现急性呕吐的程度要轻,d3、d4、d5的P〈0.05;治疗组较对照组发生迟发性呕吐的例数明显偏少且程度轻微,P〈0.01;治疗组与对照组相比,出现食欲减退的例数偏少,程度偏轻,d4、d5P〈0.01。[结论]中药敷脐联合托烷司琼可有效改善含顺铂化疗方案所致的呕吐、食欲减退,提高患者生活质量,临床研究有待进一步扩大样本、多中心、随机观察。 [Objective]To observe the effects of Tropisetron combined with herbs used externally in treatment of emesis and anorexia caused by cisplatin-based chemotherapy.[Methods]63 patients,who were consistent with the eligibility criteria of the clinical study,were divided into two groups:treatment group and control group. All the patients were received cisplatin- based chemotherapy. The patient in the treatment group were received Tropisetron and dexamethasone combined with external use of herbs to treat cisplatin-based emesis. The patients in the control group were received Tropisetron and dexamethasone alone. The symptoms of nausea,vomiting and decreased appetite during the first 5 days of chemotherapy cycle and 24 hours after5 days' chemotherapy were observed.[Results]Nausea and vomiting during the first 5 days of chemotherapy in treatment group were less serious than in control group;the incidence of dalayed vomiting and anorexia 24hours after 5 days' chemotherapy in treatment group was lower than that in control group. The difference between two groups is significant[.Conclusion]Tropisetron combined with external use of herbs is effective in treatment of nausea,emesis and anorexia caused by cisplatin-based chemotherapy. Also,the quality of life of cancer patients receiving chemotherapy is improved. For further research,a multicenter,randomized controlled treat is needed in further.
作者 毛燕 黄金昶
出处 《实用中医内科杂志》 2013年第6期11-14,共4页 Journal of Practical Traditional Chinese Internal Medicine
关键词 急性呕吐 迟发性呕吐 敷脐 托烷司琼 顺铂 食欲减退 随机平行对照研究 Tropisetron herbs used externally cisplatin acute emesis delayed emesis anorexia.
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