黄芪当归配伍对免疫功能影响的初步研究

Studies on the Immune of Astragalus and Angelica in Different Concerted Application

目的:研究黄芪当归不同配伍比例对免疫低下小鼠模型免疫作用的影响。方法:用环磷酰胺腹腔注射方法建立免疫低下小鼠模型,应用黄芪当归不同配伍比例水煎液灌胃给药,通过脏器指数、溶血素测定和淋巴细胞转化小鼠体内诱导法观察药物对免疫功能的影响。结果:模型组胸腺指数降低,各给药组与模型组比较差异无统计学意义;溶血素测定,芪归药对配比10:1高、低剂量组,5:1高、低剂量组,1:1高、低剂量组以及1:2低剂量组可促进小鼠血清IgM的产生;淋巴细胞转化率测定结果显示10:1高、低剂量组,5:1高剂量组,1:1高、低剂量组和1:2高剂量组可促进淋巴细胞的转化。结论:黄芪当归配伍不同比例有不同程度的促进免疫作用,其中芪归配比10:1、1:1对提高小鼠免疫力效果比较显著。

Objective：To study the immune effect of Astragalus and Angelica in different concerted application of low immunity in mice model .Methods： With cyclophosphamide celiac injection to establish low immunity in mice model, Astragalus and Angelica different concerted proportion decoction for intragastric administration, through the viscera index, hemolysin test and lymphocyte transformation mice revulsion to observe the effects of drugs on the immune function. Results：The thymus index of the model group decreased, the treatment group and model group comparison difference was not statistically significant; Hemolysin test, the ratio of high and low dose group 10：1, 5：1, 1：1 and low dose group 1：2 can promote the generation of mice serum IgM; The transformation of lymphocyte measurement show that high and low dose group 10：1, 1：1, high dose group 5：1, 1：2 can promote the transformation of lymphocyte. Conclusion： Astragalus and Angelica concerted different proportion have different degrees of promote the immune function, the ratio of 10：1 and 1：1 can improve mice immunity function significantly.