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Aβ介导突触损伤的分子机制研究进展

Advances in Molecular Mechanisms about All Induced Synaptotoxicity
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摘要 阿尔茨海默病（AD）是一种常见的老年认知障碍性疾病。Aβ所致的突触丧失是AD脑组织中一个较为突出的神经病理改变，是AD患者学习记忆功能减退的病理学基础。本文将近年来Aβ与突触损伤的相关性及其分子机制的研究进展作一概述。
作者 段立洁(综述) 祖衡兵(审校)
机构地区 复旦大学附属金山医院神经内科
出处 《神经疾病与精神卫生》 2013年第5期514-516,共3页 Journal of Neuroscience and Mental Health
关键词 阿尔茨海默病 AΒ 突触损伤 分子机制 Alzheimer＇s disease AmyloidAβ Synaptotoxicity Molecular mechanism
分类号 R735.7 [医药卫生—肿瘤]
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参考文献35

  • 1Kokubo H, Kayed R, Glabe CG, et al. Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain[J]. Brain Res,2005,1031(2) :222-228.
  • 2陈燕.神经元的突触可塑性与学习和记忆[J].生物化学与生物物理进展,2008,35(6):610-619. 被引量：67
  • 3Scheff SW, Price DA, Schmitt FA, et al. Hippocampal synap- tic loss in early Alzheimer's disease and mild cognitive impair- ment[J]. Neurobiol Aging,2006,27(10):1 372-1 384.
  • 4Rowan MJ, Klyubin I, Wang Q, et al. Synaptic plasticity dis- ruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies [J]. Biochem Soc Trans, 2005,33(Pt4) : 563 - 567.
  • 5Roselli F, Tirard M, Lu J, et al. Soluble β-amyloid1-40 in- duces NMDA-dependent degradation of postsynaptie density - 95 at glutamatergie synapses[J]. J Neurosci, 2005,25 (48) 11 061-11 070.
  • 6Almeida CG, Tampellini D, Takahashi RH, et al. Beta-am- yloid accumulation in APP mutant neurons reduces PSD- 95 and GluR1 in synapses[J]. Neurobiol Dis, 2005,20 (2) : 187 -198.
  • 7Zeng Y, Zhao DY, Xie CW. Neurotrophins enhance CaMKII activity and rescue amyloid-β- induced deficits in hippocam pal synaptic plasticity [J]. J Alzheimers Dis, 2010, 21 ( 3 ) :823-831.
  • 8Schmid AW, Freir DB, Herron CE. Inhibition of LTP in vivo by beta - amyloid peptide in different eonformational states [J]. Brain Res, 2008,1197 : 135- 142.
  • 9钱来,徐运.β-淀粉样蛋白对海马长时程增强的影响及作用机制[J].神经疾病与精神卫生,2011,11(1):76-79. 被引量：1
  • 10Lou H, Fan P, Perez RG, et al. Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid -β-induced neuronal cell death[J]. Bioorg Med Chem,2011, 19(13) :4 021-4 027.

二级参考文献79

  • 1闫荣,罗小光,曹云鹏,张朝东.星形胶质细胞对PC12细胞的分化及突触素和生长相关蛋白43表达的影响[J].中国医科大学学报,2006,35(1):23-25. 被引量：4
  • 2Roychaudhuri R, Yang M, Hoshi MM, et al. Amyloid beta-- Protein Assembly and Alzheimer Disease[J]. J Biolog Chem- ist,2009,284(8):4 749- 753.
  • 3Hnrt J, Lacz6 J, Vyhnfilek M, et al. Spatial navigation deficit in amnestic mild cognitive impairment[J]. Proceedings of the Na tional Academy of Sciences of lhe United States of America, 2007,104(10) :4 042-4 047.
  • 4Bliss TV,LomoT. Long- lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit fol- lowing stimulation of the perforant path[J]. J Physiology-London,1973,232(2) :331-356.
  • 5Chen QS, Wei WZ, Shimahara T, et al. Alzheimer amyloid beta --peptide inhibits 'the late phase of long--term potentiation through caleineurin--dependent mechanisms in the hippocam- pal dentate gyrus[J]. Neurobiology of l.earning and Memory, 2002,77(3) :354-371.
  • 6Wang Q, Walsh DM, Rowan M J, et al. Block of long-- term po- tentiation by naturally secreted and synthetic amyloid beta--peptide in hippocampal slices is mediated via activation of the kinases c Jnn N terminal kinase, cyclin--dependent kinase 5, and p38 mitogen- activated protein kinase as well as metabotropic glutamate receptor type 5 [J]. J Neuroscien, 2004,24(13) :3 370-3 378.
  • 7Cullen WK,Suh YH,Anwyl R,et al. Block of LTP in rat hip- poeampus in vivo by beta- amyloid precursor protein frag- ments [J]. Neuroreport,1997,8(15):3 213-3 217.
  • 8Knobloch M, Farinelli M, Konietzko U, et al. A beta oli gomer--mediated long--term potentiation impairment involves protein phosphatase 1- dependent mechanisms[J]. J Neuro seien,2007,27(29) :7 648-7 653.
  • 9Nornura I, Kato N, Kita T, et al. Mechanism of impairment of long--term potentiation by amyloid beta is independent ofNMDA receptors or voltage--dependent calcium channels in hippocampal CA1 pyramidal neurons [J]. Neuroscience Lel- ters,2005,391(1/2) :1-6.
  • 10Raymond CR,DR Ireland,WC Abraham. NMDA receptor reg- ulation by amyloid beta does not account for its inhibition ofLTP in rat hippocampus[J]. Brain Research, 2003, 968 (2) 263-272.

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神经疾病与精神卫生
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