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局部晚期非小细胞肺癌调强放疗与三维适形放疗的剂量学比较 被引量：1

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摘要 目的:比较非小细胞肺癌放疗中调强放疗(intensity modulated radiotherapy,IMRT)与三维适形放疗(three-dimensional conformal radiotherapy,3D-CRT)对靶区和危及器官的剂量学差异。方法:选择15例Ⅲ期非小细胞肺癌患者的CT定位图像,分别设计IMRT和3D-CRT计划,给予DT:64Gy/32f照射,用剂量体积直方图(DVH)评价2种治疗计划的靶区和危及器官的剂量参数。结果:IMRT计划中肺的V20、V30及肺平均剂量低于3D-CRT,而V5高于3D-CRT计划(P<0.05),V10无差异(P>0.05)。IMRT的靶区适形指数(CI)和靶区不均匀指数(HI)显著优于3D-CRT,而靶区平均剂量(PTVDmean)无明显差异(P>0.05),IMRT计划中脊髓的最大剂量(Dmax)较3D-CRT低(P<0.05),而心脏的平均剂量(Dmean)、V40和脊髓的平均剂量(Dmean)评价在IMRT及3D-CRT中差异无统计学意义(P>0.05)。结论:与三维适形放疗相比,调强放射治疗的计划可以提高靶区的适形度和均匀性,同时降低危及器官的剂量。
作者 杨燕光 刘海涛 张珏 万志龙 蔡晶 夏小春
机构地区 南通市肿瘤医院放疗科
出处 《交通医学》 2013年第5期547-548,550,共3页 Medical Journal of Communications
关键词 非小细胞肺癌 调强放疗 三维适形放疗 剂量体积直方图
分类号 R734.2 [医药卫生—肿瘤]
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参考文献9

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二级参考文献24

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交通医学
2013年 第5期

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