EV71感染手足口病患儿血清中肺表面活性蛋白A水平测定及临床意义

SP-A level of EV71 infected HFMD children and its clinical significance

目的:探讨EV71感染手足口病患儿血清中肺表面活性蛋白A(SP-A)水平,并探讨其临床意义。方法:选取2011年3月-2011年11月河北医科大学附属邢台市人民医院儿科收治的EV71感染手足口病患儿50名,分为普通组、重症组和危重症组。同期该院门诊体检健康儿童30名作为正常对照组,采用ELISA定量法检测各组患儿血清SP-A水平。结果:普通组和重症组血清SP-A水平与对照组比较差异无统计学意义(P>0.05),危重症组血清SP-A水平明显高于对照组、普通组及重症组,差异有统计学意义(P<0.05)。结论:检测手足口病患儿血清SP-A水平是危重症患儿急性肺损伤早期诊断的重要辅助指标。

Objective：To investigate pulmonary surfactant protein A （SP-A） level and its clinical significance for children pa-tients with Hand Foot and Mouth Disease （HFMD） infected by Enterovirus 71 （EV71）. Methods ：50 EV71 infected HFMD children in Xiangtai people/s hospital affiliated to Hebei medical university from Mar. 2011 to Nov. 2011 were selected and divided into ordina- ry group, severe group and critical group, and 30 healthy children for physical examination in the clinic were chosen as control group. The serum SP-A levels were detected by enzyme-linked immunosorbent assay （ELASA）. Results： Differences of the SP-A levels a-mong ordinary group, severe group and control group were not statistically significant （P〉0.05）. Moreover, the SP-A level of critical group was obviously higher than those of the other three groups, and the differences were statistically significant （P〈0.05）. Conclu-sions： The SP-A level of the children with HFMD is an important auxiliary indicator to identify the acute lung injury at the early stage.