摘要
目的研究甲钴胺辅助治疗急性吉兰-巴雷综合征(GBS)的临床效果,以及相对于单纯免疫球蛋白治疗的优势。方法采取随机对照的方法,将符合急性吉兰-巴雷综合征诊断标准的60例患者,分为2组,每组各30例。2组在丙型球蛋白治疗的基础上,治疗组注射甲钴胺,对照组给予生理盐水,观察临床症状改善时间以及疗效,然后进行统计学分析。结果 (1)在临床疗效Hughes评分方面,甲钴胺治疗组8周后与生理盐水对照组相比,症状有明显的改善;(2)在临床疗效MRC评分方面,治疗组4周与对照组患者相比,症状得到明显缓解;(3)治疗组的平均好转时间显著少于对照组。结论与单纯的丙型球蛋白基础免疫治疗相比,甲钴胺联合治疗吉兰-巴雷综合征有较好的疗效。
Objective To observe the clinical therapeutic effects of Methylcobalamin in treating the Guillain-Barre Syn- drome and the potential advantages of combined therapy over single IVIG therapy. Methods Sixty cases with acute Guillain- Barre Syndrome were divided into two groups. One is treatment group (Methylcobalamin injection 500μg), and the other is control group (physiological saline injection). Both treatments were administered three times a week. For all the patients, IVIG in was used as the basic therapy. The improvement of neurological functioncharacterized by Hughes and MRC evaluation systems was observed together with the average turn-around time. Results Significant differences in Medical Research Council (MRC)-score were observed after 4-week between the treatment group and the control group. After 8-week, there are also sig- nificant differences in Hughes-score between the two groups. After the therapy, the average turn-around time improved dra- matically, compared with the control group. Conclusion Methylcobalamin is an effective method in the treatment of acuteGBS. The improvement of neurological function was observed.
出处
《中国实用神经疾病杂志》
2013年第21期29-30,共2页
Chinese Journal of Practical Nervous Diseases