糖尿病并脑梗死患者氧化型低密度脂蛋白检测及临床意义

Detection of oxide low density lipoprotein in diabetes patients complicated with cerebral infarction and its clinical significance

目的通过检测合并糖尿病的急性脑梗死患者血浆中氧化型低密度脂蛋白(ox-LDL)水平,探讨其与病灶特点、病情轻重、临床转归的关系。方法选择发病48h内的急性脑梗死患者124例,其中合并糖尿病组64例,无糖尿病组60例。选择同期住院的其他类型缺血性脑血管病(TIA及眩晕症)患者71例为对照组。所有患者均采用国内统一试剂盒进行oxLDL水平测定。结果脑梗死合并糖尿病组ox-LDL水平明显高于无糖尿病组及对照组,差异有统计学意义(P<0.05);合并糖尿病组腔隙性梗死比例相对较高,且与无糖尿病组相比,病情进展率、重型比例高,临床转归较差。结论糖尿病并急性脑梗死患者ox-LDI水平显著增高,且与脑梗死病情进展及病情轻重相关。

Objective To test Oxidation of plasma low density lipoprotein （ox-LDL） levels within Diabetic patients with cerebral infarction and nondiabetic patients with cerebral infarction and to explore the relationship between the outcome and the lesions, severity, clinical characteristics. Methods We selected 124 patients with acute ischemic stroke within 48 hours, diabe-tes group 64 cases, no diabetes group 60 cases. 71 cases of other types of ischemic cerebral vascular disease were selected as a con-trol group. Serum ox-LDL levels of them were detected. Results Ox-LDL levels of diabetes group was significantly＇ higher than that in non diabetic group and control group （P%0.05）. Proportion of merger diabetic lacunar infarction was higher in diabetes group than other two group, and compared with no diabetes group , the rate of progression of the disease, severe cases and poor prognosis were significantly higher. Conclusion ox-LDL levels in patients with diabetes mellitus complicated with acute cerebral infarction may significantly increased and it has great correlation with the progress and severity of the disease.