初发腔隙性梗死病人与代谢综合征关系的研究

Study on association between first-ever lacunar cerebral infarction and metabolic syndrome

目的探讨腔隙性梗死病人代谢综合征的患病率及与各亚型之间的关系。方法选择138例初发腔隙性梗死患者及年龄、性别相匹配的138例初发动脉硬化性皮层梗死患者,根据有无白质损害,观察腔隙性梗死患者代谢综合征的患病率及与腔隙性梗死亚型的关系。结果皮层梗死组代谢综合征的患病率(45.7%)高于腔隙性梗死组(35.9%)(P<0.01)。无白质损害的腔隙性梗死患者代谢综合征的患病率高于有白质损害者,皮层梗死组代谢综合征患病率高于有白质损害的腔隙性梗死组。结论代谢综合征的患病率与不伴白质损害的腔隙性梗死明显相关,皮层梗死的患病率高于有白质损害的腔隙性梗死,与各型梗死之间的发病机制不同有关。

Objective To explore the prevalence of lacunar cerebral infarction patients with metabolic syndrome and the re- lationship between the subtypes. Methods 138 cases with first-ever lacunar cerebral infarction and 138 cases of first-ever ather- osclerotic cortical infarction who matched for age and sex were retrospectively selected . According to with or without white matter lesions, we observed the prevalence of metabolic syndrome in lacunar cerebral infarction and the association between metabolic syndrome with lacunar cerebral infarction subtypes. Results There were no significant difference between two groups in ages, and the prevalent of metabolic syndrome in cortical infarction patients was more than patients with lacunar infarction, 45.7% and 35.9% respectively （P〈0.01）. Metabolic syndrome was more prevalent in lacunar cerebral infarction without white matter lesions than in lacunar cerebral infarction with white matter lesions. Similarly, metabolic syndrome related more to cortical infarction compared to lacunar infarction white matter lesions. Conclusion Metabolic syndrome assocviates more strongly to lacunar cerebral infarction without white matter lesions and to cortical infarction, than to lacunar cerebral infarction with white matter lesions.