文拉法辛联合阿立哌唑治疗难治性抑郁症的临床疗效及对认知功能的影响

The effect of venlafaxine combined with aripiprazole on intractable depression and the influence on cognitive function

目的探讨文拉法辛联合阿立哌唑治疗难治性抑郁症的临床疗效及对认知功能的影响。方法将128例难治性抑郁症患者随机分为对照组与观察组,对照组患者给予文拉法辛口服,观察组给予文拉法辛联合阿立哌唑治疗,疗程8周。比较2组临床疗效、认知功能及药物不良反应的差别。结果治疗8周后观察组汉密尔顿抑郁量表(HAMD)各项评分显著低于对照组(P<0.05);观察组认知功能威斯康星卡片分类测验(WCST)正确反应数及完成分类数评分显著优于对照组(P<0.05);2组不良反应无显著差别(P<0.05)。结论文拉法辛联合阿立哌唑治疗难治性抑郁症可显著提高临床疗效、改善认知功能,且不增加不良反应。

Objective To explore the clinical effect of venlafaxine combined with aripiprazole on intractable depression. Methods 128 cases with intractable depression were randomly divided into control group and study group. Control group were given venlafaxine treatment, and study group received venlafaxine combined with aripiprazole therapy. The treatment course was 8 weeks. Clinical effect, cognitive function and adverse reaction were compared between two groups. Results HAMD scores in study group on 8 weeks after treatment were significantly lower than those in control group （P〈0.05） ; Categoriesa- chieved and preservativeerrors of WCST scores in experience group were superior to control group （P〈0.05） ; There were no significant difference of adverse rates in two groups （P〉0.05）. Conclusion Venlafaxine combined with aripiprazole for intrac- table depression greatly improve the clinical effect and cognitive function with less adverse reaction.