活性炭灌流器对急性中毒患者血糖的吸附规律研究

The adsorption regularity of activated charcoal hemoperfusion for blood glucose in patients with acute intoxication

目的研究活性炭灌流器对急性中毒患者血糖的吸附规律。方法选择2011年3月至2012年8月于天津医科大学总医院收治并行血液灌流(HP)的急性中毒患者共30例。对所有患者进行活性炭HP,监测急性中毒患者HP开始时及20、30、40、60、90和120 min血液灌流器对血糖的吸附值。计算血糖吸附率,比较活性炭灌流器在各时间点对血糖吸附能力的差异。结果与其他时间点相比,治疗开始时和治疗20 min,活性炭灌流器对血糖吸附率最大(P均<0.05)。与治疗90 min和120 min相比,治疗30 min至60 min时吸附率较大(P均<0.05)。其他时间点的吸附率无明显差异(P均>0.05)。结论 HP治疗的前20 min内活性炭灌流器吸附血糖能力最强,以后吸附能力下降,至90 min接近吸附平衡。此规律可能有助于决定HP的治疗时间。

Objective To investigate the adsorption regularity of activated charcoal hemoperfusion for blood glucose in patients with acute intoxication. Methods The acutely poisoned patients treated with charcoal hemoperfusion （HP） in the General Hospital of Tianjin Medical University between March 2011 and August 2012 were included in the perspective study. Of all the cases, the hemoperfusion cartridge were monitored for the adsorption of the blood glucose at the start of HP, 20, 30, 40, 60, 90 and 120 rain after the HP treatment. The adsorption rates of blood glucose at all the 7 time points were respectively determined and compared with each other. Results The adsorption rate of blood glucose at 20 min of the treatment was remarkably higher than those at the rest other time points （all P 〈 0.05）. Comparing with the 90 and 120 min respectively, adsorption rates at 30, 40 and 60 rain were siguificantly higher （all P 〈 0.05）. There were no statistical differences in the adsorption rate between other time points. Conclusions Within the first 20 min during the HP, the rate of charcoal hemoperfusion for blood glucose was significantly higher, it gradually declined with time prolonged and reached equilibrium at 90 min after the treatment. The regularity may be valuable in determining the duration of HP.