循环肿瘤细胞:新的肺癌相关肿瘤标志物
摘要
循环肿瘤细胞(circulating tumor cell,CTC)计数与乳腺癌、大肠癌和前列腺癌的无进展生存期(progression free survival,PFS)和总生存期(overall survival,os)不佳相关。在肺癌治疗过程中,需要大量可以监测患者疾病进展的多功能肿瘤生物标志物。研究[1-2]发现,肺癌的主要治疗方法——手术治疗,可引起CTC的增加。这有可能造成不同的残留病灶,即使是在全肿瘤切除的成功病例中也是如此。在有关肺癌的CTC研究中,
出处
《国际病理科学与临床杂志》
CAS
2013年第5期369-370,共2页
Journal of International Pathology and Clinical Medicine
参考文献12
-
1Goldfarb Y, Ben-Eliyahu S. Surgery as a risk fator breast cancer recurrence and metastasis: mediating mechanisms and clinical prophylactic approaches[]]. Breast Dis, 2006-2007, 26: 99-114.
-
2Momma T, Hamblin MR, Wu HC, et al. Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis[]]' Cancer Res, 1998, 58(23): 5425-5431.
-
3Wendel M, Bazhenova L, Boshuizen R, et al. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology[]]. Phys BioI, 2012, 9(1): 016005.
-
4Nieva], Wendel M, Luttgen MS, et al. High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis[]]. Phys Biol, 2012, 9( 1): 016004.
-
5Marrinucci D, Bethel K, Kolatkar A, et al. Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers[]]. Phys BioI, 2012, 9(1):016003.
-
6Cristofanilli M, Hayes DF, Budd GT, et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer[]].] Clin Oncol, 2005, 23(7): 1420-1430.
-
7Cristofanilli M, Broglio KR, Guarneri V, et al. Circulating tumor cells in metastatic breast cancer: biologic staging beyond turrior burdenlJ]. Clin Breast Cancer, 2007, 7(6): 471-479.
-
8Cho EH, Wendel M, Luttgen M, et al. Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors[J]. Phys BioI, 2012, 9(1): 016001.
-
9Schmid K, OeW N, Wrba F, et al. EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding loco regional lymph node metastases[]]' Clin Cancer Res, 2009,15(14): 4554-4560.
-
10Newton PK, Mason], Bethel K, et al. A stochastic Markov chain model to describe lung cancer growth and metastasislJ]. PLoS One, 2012, 7(4): e34637.
-
1尤寅骏,周贤梅.呼出气冷凝液生物标志物检测在肺癌中的研究进展[J].国际呼吸杂志,2011,31(4):308-311.
-
2袁秀荣.肿瘤生物标志物的临床应用[J].国外医学(肿瘤学分册),1997,24(2):83-86. 被引量:12
-
3钟凯华,柳建军.RASSF1A和肿瘤的研究新进展[J].现代肿瘤医学,2006,14(2):250-252. 被引量:1
-
4曾瑶,李晓星,于君.胃癌中甲基化的作用及相关预后标志物研究进展[J].新医学,2014,45(2):71-78. 被引量:2
-
5靳京,孙秀华.HER-2/neu基因在结肠癌诊治中的研究进展[J].医学综述,2014,20(9):1577-1579. 被引量:3
-
6姚群峰,周宜开,任恕.基因启动子异常甲基化及其作为肿瘤生物标志物的研究进展[J].国外医学(分子生物学分册),2003,25(3):162-165. 被引量:2
-
7王会中,任成山,金发光.肿瘤生物标志物在肺癌患者检测中的临床意义及研究进展[J].中华肺部疾病杂志(电子版),2016,9(3):329-333. 被引量:25
-
8邓君,洪华,传良敏,孙昌瑞.C-ERBB2和MYC mRNA基因表达水平在乳腺癌诊断的临床应用[J].成都医学院学报,2014,9(6):683-685. 被引量:3
-
9孙慧.乳腺癌患者CTC的检测及临床意义[J].医学信息(下旬刊),2010,23(11):49-50.
-
10平伟,付向宁.肺癌循环肿瘤细胞临床应用的研究进展[J].中国肺癌杂志,2011,14(6):543-546. 被引量:5