期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

p-eIF4E在肿瘤中作用的研究进展 被引量：3

Research progress in relation between phosphorylation of eIF4E and tumor
下载PDF
导出
摘要 真核细胞翻译起始因子4E(eukaryotic initiation factor 4E,eIF4E)是蛋白质翻译起始的关键因子,磷酸化eIF4E(p-eIF4E)与真核生物蛋白质合成及与肿瘤的发生、发展、侵袭、转移和预后密切相关。p-eIF4E的异常表达参与了前列腺癌、淋巴瘤以及肺癌等多种肿瘤的发生、发展。 Eukaryotic translation initiation factor 4E （eIF4E） is the most important translation initiation factor for protein translation. Phosphorylation of eIF4E is closely related to the eukaryotic protein synthesis and tumor occurrence, development, metastasis and prognosis. The abnormal level ofp-eIF4E is involved in the occurrence and development of many tumors such as prostatic cancer, lymphoma and lung cancer.
作者 李姣 郑军 范松青
机构地区 中南大学湘雅二医院病理科 长治医学院生物化学教研室
出处 《国际病理科学与临床杂志》 CAS 2013年第5期389-393,共5页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金(81272566)~~
关键词 真核细胞翻译起始因子 磷酸化 肿瘤 eukaryotic initiation factor 4E phosphorylation tumor
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1Joshi B, Cameron A,]agus R. Characterization of mammalian elF4E Familymem- bers[J]. EurJ Biochem, 2004, 271(1l): 2189-2203.
  • 2Culjkovic B, Topisirovic I, Skrabanek L, et al. eIF4E is a central node of an RNA regulon that governs cellular proliferation[]].] Cell Bioi, 2006,175(3): 415-426.
  • 3Culjkovic B, Topisirovic I, Borden KL. Controlling gene expression through RNA reguIons: the role of the eukaryotic translation initiation factor eIF4E[]]. Cell Cycle, 2007, 6(1): 65-69.
  • 4Wilhelm JE, Hilton M, Amos Q. et al. Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz[]]' J Cell Bioi, 2003, 163(6): ll97 -1204.
  • 5GraffJR, Zimmer SG. Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF4E selectively enhances translation of metastasis-related mRNAs [J]. Clin Exp Metastasis, 2003, 20(3): 265-273.
  • 6Wendel HG, Silva RL, Malina A, et al. Dissecting eIF4E action in tumorigenesis[J]. Genes Dev, 2007, 21(24): 3232-3237.
  • 7Topisirovic I, Ruiz-Gutierrez M, Borden kL. Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities[J]. Cancer Res, 2004, 64(23):8639-8642.
  • 8Zuberek], Jemielity J,]ablonowska A, et al. Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5'terrninus[J]. Biochemistry, 2004, 43( 18) : 5370-5379.
  • 9Lachance PE, Miron M, Raught B, et al. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth[J]. Mol Cell Bioi, 2002,22(6): 1656-1663.
  • 10Minich WB, Balasta ML, Goss D], et al. Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotie translationinitiatio factor 4E: increased cap affmity of the phosphorylated form[J]. Proc Nat! Acad Sci USA, 1994,91(16): 7668-7672.

二级参考文献2

共引文献1

同被引文献15

  • 1潘保见,陈嘉薇,祝峰.宫颈鳞癌和癌前病变中eIF-4E表达及其与HPV16/18感染的关系[J].临床与实验病理学杂志,2007,23(5):528-531. 被引量：9
  • 2De Benedetti A, Graft JR. eIF4E expression and its role in malig- nancines and metastases [ J ]. Oncogene, 2004, 23 ( 18 ) : 3189 -3199.
  • 3Vonder Ham" T,Gro6s JD,Wagner G,et al. The mRNA cap binding protein eIF4E in post transcriptional gene expression[ J]. Nat Street Mol Biol,2004,11 (6) :503.
  • 4Pavelic Z, Pavelie K, Cater C, et al. Heterogenity of c - myc expres- sion in histologically similar infiltrating ductal carinomas of the breast [ J ]. J Cancer Res Clin Oncol, 1992,118 : 16 - 22.
  • 5Sharma S, Baksi R, Agarwal M, et al. Repositioning of anti - viral drags as therapy for cervical cancer [ J ]. Pharmacol Rep, 2016,68 (5) :983 -989.
  • 6Attar Schneider O, Drucker L, Gottfried M1, et al. Migration and ep- ithelial to mesenchymal transition of lung cancer can be targeted Via translation initiation factors elF4E and elF4G [ J]. Lab Invest, 2016,8 : 1038.
  • 7Ho JJ, Lee S. A cap for every occasion: ahemative elF4F complexes[J]. Trends Biochem Sci,2016,6(10) :1016.
  • 8Iyer VV. A Review of stapled peptides and small molecules to inhib- it protein interactions in cancer [ J ]. Curr Med Chem,2016,6 (26) : 243 - 247.
  • 9林宇,许惠玉,邹宇,等.elF4E基因下调对人乳腺癌基因Bcap37细胞凋亡的影响[J].医学研究杂志,2013,4(14):134—136.
  • 10Millican Slater RA, Sayers CD, Hanby AM, et al. Expression of phosphorylated elF4E -binding protein 1 ,but not of eIF4E itself, predicts survival in male breast cancer [ J ]. Br J Cancer, 2016, 115(3) :339 -345.

引证文献3

二级引证文献6

国际病理科学与临床杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部