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ATM基因及其蛋白在动脉粥样硬化中的作用及机制 被引量：1

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摘要 共济失调毛细血管扩张症(AT)是一种常染色体隐性遗传性疾病,临床表现为多功能损伤,并伴有高血脂及高胆固醇血症,其致病基因为ATM。ATM基因及其编码的蛋白是机体维持稳定的重要蛋白,能够修复体内的DNA双链断裂,抑制机体氧化应激,降低血管内皮损伤,稳定机体内分泌协调等,而这一系列作用都与动脉粥样硬化的发生发展密切相关,通过就ATM基因及ATM蛋白与动脉粥样硬化的关系做一综述,以供参考。
作者 肖艳红 刘娟 吴建华 吴东方
机构地区 武汉大学中南医院药学部 中山大学附属第六医院检验科 恩施土家族苗族自治州中心医院
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2013年第22期1877-1880,共4页 Chinese Journal of Hospital Pharmacy
基金 国家自然科学基金项目(编号:30971428)
关键词 动脉粥样硬化 ATM基因 高脂血症
分类号 R966 [医药卫生—药理学]
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中国医院药学杂志
2013年 第22期

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