勿动蛋白及NgR的下游信号通路研究进展

Downstream signaling pathways of Nogo and NgR

哺乳动物中枢神经系统(CNS)损伤后不能再生,目前认为主要原因包括胶质瘢痕的机械阻碍作用、促神经生长因子的缺乏及中枢神经系统中抑制因子的存在;而抑制因子的存在被认为是最重要的原因。其中,勿动蛋白(Nogo)作为抑制中枢神经系统再生的最重要的物质,越来越受人们的重视。近年越来越多研究表明Nogo不仅抑制损伤后CNS的再生,在正常生理情况下也起着重要的作用,Nogo对轴索生长的抑制及正常生理过程的作用涉及多种信号分子及信号通路,理解Nogo通过不同的信号转导途径引起的不同生物学效应对于早日攻破中枢神经系统再生这个难题有至关重要的作用,因此,该文就近年来对Nogo及其受体NgR的下游信号通路的研究进展予以综述。

Mammalian central nervous system （ CNS） cannot regenerate after injury , which main due to the role of glial scar mechanical obstruction , the deficiency of promoting nerve growth factor and the presence of the inhibitors.The presence of inhibitors is considered to be the most important reason.Nogo, as the most important material to suppress the central nervous system regeneration , is getting more attention.In recent years , more and more studies show that Nogo not only inhibits the regeneration of injured CNS , but also plays an important role in the normal physiological process.Nogo on the inhibition of axonal growth and normal physiological processes have involved in a variety of signaling molecules and signaling pathways .It is important to make it clear how Nogo works through different signal transduction pathways caused by the biological effects , which has a crucial role for the early break of CNS regeneration problem.Therefore, Nogo and the downstream signaling pathway of its receoptor-NgR have been reviewed in this papper.