偏头痛与卵圆孔未闭关系的研究

Prevalence and size of patent foramen ovale in patients with migraine

目的探讨先兆性偏头痛、无先兆性偏头痛患者和正常人卵圆孔未闭(PFO)发生率的差异。方法采用经颅多普勒超声(TCD)检测先兆性偏头痛组(29例)、无先兆偏头痛组(31例)和正常对照组(26名)PFO的发生率,比较各组差异。记录治疗前偏头痛患者的头痛频率、头痛发作日数和头痛程度等,并分析其与PFD分流量大小的相关性。结果先兆性偏头痛组、无先兆偏头痛组和正常对照组PFO发生率分别为72%、45%和31%,先兆偏头痛组PFO发生率较正常对照组高(P=0.008),无先兆偏头痛组较正常对照组高,但比较差异尚无统计学意义(P=0.491);PFO大小与头痛频率、头痛发作日数呈正相关(P均<0.05)。结论先兆偏头痛患者的PFO发生率较高,提示此两种疾病可能有共同的病理学发病机制。

Objective To explore the difference in prevalence of patent foramen ovale （ PFO） be-tween migraine patients （ with or without aura ） and healthy person without migraine.Methods Transcranial doppler was used to assess the prevalence of PFO in migraine with aura group （ 29 cases ） , migraine without aura group （31 cases） and healthy-control group （26 cases）, compared the difference among the groups.The headache frequency , the headache days and the degree of headache before treatment in migraine patients were recorded , their correlation with the shunt size of PFO were analyzed.Results The prevalence of PFO were 72%, 45%and 31%in migraine with aura group , migraine without aura group and healthy-control group , re-spectively.The difference between migraine with aura group and healthy-control group was statistically signifi-cant （P=0.008）.The headache frequency and the headache days positively related with the shunt size of PFO （ P〈0.05 ）.Conclusion The higher prevalence of PFO in migraine with aura could prompt the common pathogenesis between these two diseases.