对克隆氏病及溃疡性结肠炎患儿血中抗氧化剂的观察

CIRCULATING ANTIOXIDANT CONCENTRATIONS IN CHILDREN WITH CROHN DISEASE AND ULCERATIVE COLITIS

目的 :探讨儿童克隆氏病 (Crohn’sdisease ,CD)及溃疡性结肠炎 (UlcerativeColitis,UC)血中抗氧化剂的变化。方法 :对 8例CD和 7例UC患儿进行营养学评分 ,另选 8例正常儿童作为对照。测定其血中抗坏血酸 ,谷胱苷肽及谷胱苷肽过氧化物酶 ,视黄醇及视黄醇结合蛋白和血硒的含量 ,并与正常对照组进行比较。结果 :CD患儿其营养状态明显差于UC及正常儿童 ,同时血浆中抗坏血酸含量明显降低 ,而谷胱苷肽及谷胱苷肽过氧化酶、α-生育酚含量明显增高 ,UC患儿尽管亦有增高的趋势 ,但与正常对照组比较并无明显的差异。结论 :CD患儿血中存在抗氧化物的明显改变 ,这可能与该病的发生有关。

Objective: To determine whether antioxidant defenses might be altered, we evaluated plasma antioxidant concentrations in children with Crohn disease and ulcerative colitis. Methods: In 23 child were rolled to study (8 with Crohn disease, 7 with ulcerative colitis and 8 healthy child), anthropometric measurements and disease activity scores were obtained. The concentrations plasma ascorbic acid, glutathione peroxidase, glutathione, and α-tocopherol were measured. Results: The children with Crohn disease were malnourished compared with the ulcerative colitis and control groups. Children with Crohn disease and ulcerative colitis had low plasma ascorbic acid and increased glutathione peroxidase, glutathione, and α-tocopherol concentrations compared with control subjects. Conclusions: This study provides evidence that children with Crohn disease have alterations in circulating antioxidant defenses, possibly related to a general of this disease.