抽动-秽语综合征患儿尿香草扁桃酸的变化及意义

Changes and significances of monoamine neurotransmitter vanillyl mandelic acids in urine of Tourette's syndrome patients

目的了解抽动-秽语综合征(tourette’s syndrome,TS)患儿尿单氨类神经递质代谢产物香草扁桃酸(vanillylmandelic acid,VMA)水平,探讨其与疾病发生的意义。方法以40例TS患儿为病例组,33例健康儿童作为正常对照组。采集研究对象的尿液,经高效液相色谱法分离后利用库仑阵列电化学检测香草扁桃酸(VMA)水平,紫外检测器检测作为校正因素的肌酐含量。利用VMA/Cr代表尿样中VMA的水平。结果病例组尿液VMA/Cr值为:(1.597±0.095)μg/mg,对照组VMA/Cr值为(2.198±0.112)μg/mg,病例组尿液VMA/Cr均值显著低于对照组(P<0.001),病例组和对照组VMA/Cr均值男女之间差异均无统计学意义。结论 TS患儿中存在VMA水平异常。

Objective To study the levels of urinary vanillylmandelic acid （VMA） metabolite in children with Tourette ＇ s syndrome （TS） and its relationship with disease significance. Methods VMA levels in fresh urine of 40 Childrem with TS as study group and in 33 healthy children＇ s urine as normal controls were measured by high performance liquid chromatography coulometric electrochemical array, and urine creatinine （Cr） was used for correction. Results VMA/Cr value in urine of study group was （ 1. 597 ±0. 095 ）μg/mg, and VMA/Cr value in control group was （2. 198 ±0.112） μg/mg. Value of VMA/Cr in urine of study group was significantly lower than that the control group（ P 〈 0. 001 ） and mean values of VMA/Cr were not significantly different in the study group and control group between men and women. Conclusion VMA level is abnormal in with Tourette＇ s syndrome children.