小剂量肝素在肺心病急性加重期中的作用

Effect of small dose heparin in patients of cor pulmonale in acutely deteriorative stage

目的 :观察小剂量肝素对肺源性心脏病 (肺心病 )急性加重期患者的血粘度、凝血功能及血气分析的影响。方法 :12 0例肺心病急性加重期患者在常规治疗基础上 ,用小剂量肝素 5 0 m g加入 5 %～ 10 %葡萄糖液5 0 0 m l静滴 ,每日 1次 ,疗程 1周 ,观察血粘度 ,血小板、凝血功能及血气变化。结果 :小剂量肝素抑制在凝血因子 阶段的血液凝固过程 ,同时改变血粘度 ,降低血小板聚集率及降低纤维蛋白原含量 ,改善肺循环。结论 :应用小剂量肝素干预血粘度、血小板和凝血功能 ,有效地改善了患者的血液性状 。

Objective:To observe the influences of small dose heparin on blood viscosity,coagulative function,and blood gas analysis in patients with acutely deteriorative stage of cor pulmonale.Methods:One hundred and twenty cases with acutely deteriorative stage of cor pulmonale based on conventional therapy were treated with small dose heparin 50 mg+5%10% glucose 500 ml infused intravenously once a day for one week as a therapeutic course.The changes in blood viscosity,platelet,coagulative function,and blood gas were observed.Results:Small dose heparin could inhibit the coagulation process during the phase of coagulative factor Ⅹ and vary the blood viscosity,decrease the aggregative rate of platelets and the content of fibrinogen,meanwhile improve the pulmonary circulation.Conclusions:Small dose heparin used is able to intervene the blood viscosity,platelet,and coagulative function,to improve the blood character effectively so that it is beneficial to treatment for acutely deteriorative stage of cor pulmonale.