P53、ras基因在肺腺癌组织中的表达及意义

Significance of P53 and ras expression in pulmonary adenocarcinoma

目的 了解P5 3基因及ras基因在肺腺癌中的表达特点及与预后的关系。方法 采用免疫组化法对 5 3例肺腺癌组织中P5 3及ras蛋白进行检测 ,分组随访。结果 肺腺癌组织中P5 3、ras蛋白阳性表达率分别为 5 4.72 %、6 6 .38% ,淋巴结转移组阳性表达率 (78.13 %、84.38% )高于无淋巴结癌转移组 ;低分化者阳性表达率 (81.82 %、86 .36 % )高于高分化组 ;阴性组 1年存活率高于阳性组。结论 P5 3、ras表达和肺腺癌生物学行为有关 ,可作为判断预后的参考指标。

Objective To study the significance of p53 and ras expression in adenocarcinoma of the pulmonary.Methods Expression of p53 and ras in 53 cases of adenocarcinoma of the pulmonary was examined by immunohistochemistry.Results p53 protein was detected in 54.72% cases of pulmonary adenocarcinoma,ras protein was detected in 66.38% cases.Positive rate of p53 protein and ras protein was higher in the group of lymphatic metastasis and the group of poor differentiation than in the group of nolymphatic metastasis and the group of well differeniation.The 1 year survival rate of positive group of p53 protein and ras protein was lower than that of negative group.Conclusions p53 and ras were associated with malignant biological behavior and poor prognosis of pulmonary adenocarcinoma,which mya be potential prognostic factors in pulmonary adenocarcinoma. [