摘要
目的 探讨MTS1基因在胃癌中的表达规律及其临床意义。方法 应用免疫组织化学LSAB方法 ,对 6 5例胃癌的MTS1基因产物p16的表达进行了观察。结果 MTS1基因产物的表达与胃癌的分化程度和预后呈正相关 ,与浸润、淋巴结转移呈负相关。结论 MTS1参与了胃癌的发展过程 ,并与胃癌的部分生物学行为有关 ,可能成为胃癌诊断和判断预后的重要的分子生物学检测指标。
Objective To study the expression of MTS1 in gastric cancer and its clincial significance.Methods MTS1 gene products were observed in 65 gastric cancer with LSAB immunohistochemical methods.Results Expression of MTS1 was positively related to the degree of differentiation and the prognosis of patient and negatively related to the depth of invasion and lymph node metastasis.Conclusions MTS1 may play some roles in the development of gastric cancer,and was related with partial biological behavior.Expression of MTS1 may serve as an important molecular biological indicator in diagnosing and predicting the prognosis of gastric cancer.[
出处
《中国肿瘤临床与康复》
2000年第6期21-22,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
