原发性肝癌血清一氧化氮的研究

Study on nitric oxide in serum of primary hepatocarcinoma

目的 探讨原发性肝癌血清一氧化氮 (NO)含量变化及其临床意义。方法 检测 2 1例中晚期原发性肝癌患者及 36例健康对照者血清亚硝酸盐水平间接反应血清NO的含量 ,前者与所测量瘤体最大径进行相关分析。结果 原发性肝癌患者血清NO(12 .34± 3 .0 6 μmol/L)明显高于健康对照组 (9.6 6± 1.5 2 μmol/L) (P <0 .0 1)。原发性肝癌患者血清NO与肿瘤直径呈正相关关系 (r =0 .5 132 ,P =0 .0 174)。结论 NO在原发性肝癌的发生发展中起重要作用 ,肝癌患者血清NO水平测定对肝癌诊断、治疗及预后的评价具有一定的意义。

Objective To explore the level of NO in serum of primary hepatocarcinoma and evaluate its clinic significance.Methods NO was estimated by detecting nitrite in serum of 21 primary hepatocarcinoma hepatitis including intermediated and advanced stage,and 36 health controls.Results Experiments showed that the concentration of NO was significantly higher in primary hepatocarcinoma(12.34±3.06μml/L) than that of healthy controls (9.66±1.52μml/L),P<0.01.There were positive correlations between NO and the tumor diameter(r=0.5132,P=0.0174).Conclusions NO plays an important role in the genesis and development of the primary hepatocarcinoma,whose data are of great value for diagnosing、treating and predicting prognosis of the primary hepatocarcinoma. [