超选择髂内动脉化疗栓塞术治疗晚期盆腔恶性肿瘤

Ultra-selective internal iliac arterial chemo-embolization for advanced pelvic cancer

目的 应用动脉导管超选择性技术治疗晚期及复发性盆腔恶性肿瘤 6 7例。方法 应用Seldinger法一侧股动脉插管 ,将导管超选至双侧髂内动脉的肿瘤直接供血动脉 ,经导管灌注抗癌药物后 ,应用碘油 (与大剂量顺铂混合 )及明胶海绵栓塞。结果 完全有效 2 5 .4%、部分有效 71.6 %、轻微有效 3 .0 %。半年、1年、2年生存率分别为 :10 0 %、74.6 %、5 5 .2 %。无严重合并症病例发生。结论 我们认为经导管超选择髂内动脉灌注大剂量顺铂化疗与碘油、明胶海绵栓塞联合应用治疗晚期及复发性盆腔恶性肿瘤是安全有效的。

Objective Transcatheter ultra selective bilateral iliac arterial chemoembolization were performed in patients with advanced or recurrent plevic malignant tumors.Methods Transcatheter bilateral iliac arterial chemoembolization using lipiodol,gelfoam fragment and HD DDP were performed in 67 patients with advanced or recurrent pelvic malignant tumors.Results Complete response and partial response to the therapy were observed in 17 and 48 patients respectively.The 6 month, 12 month,24 month survival rate were 100%(67/67),74.6%(50/67),55.2%(37/67) respectively.No severe complications occurred after lipiodol and gelfoam embolization and HD DDP chemotherapy.Conclusions Transcatheter ultra selective bilateral iliac arterial chemoembolization using lipiodol,gelfoam fragment and HD DDP can be regarded as a safe and effective method for advanced or recurrent pelvic malignant tumors. [