α-受体阻滞剂治疗高血压合并前列腺增生的临床观察

Clinical observation of α-Recepter Blockade Treatment of Hypertersion Associated with Prostatic Hyperplasia

目的 :用α 受体阻滞剂治疗高血压合并前列腺增生的病人 ,观察这类药物对前列腺有无有益的作用。方法 :5 8例病人用α 受体阻滞剂 ,包括哌唑嗪 2 7例 ,特拉唑嗪31例 ,随访 3个月、6个月 ,观察血压、去甲肾上腺素 (NE)、肾素 (E)及前列腺大小 ,比较治疗前后变化。结果 :治疗后血压明显下降 (P <0 0 0 1) ,去甲肾上腺素、肾素无变化 (P >0 0 5 ) ,前列腺体积也有缩小 ,(6个月P <0 0 5 )。结论 :α 受体阻滞剂有降压及缩小前列腺的作用 ,适合于高血压并前列腺增生的病人。

objective:To study the efficacy of α receptor blockade drugs on prostate in the treatment of hypertersion associated with prostatic hyperplasia. Methods:Among 58 patients treated with α receptor blockade drugs,27 with prazosin was followed up 3 months,31 with terazosin was six months. Levels of blood pressure.noradrenaline.adrenaline and sizes of prostate were measured in these patients to show the variations before and following the treatment. Results:Blood pressure lowered significantly( \%P\%< 0 001).the levels of noradrenaline,adrenaline didn't varied( \%P\%> 0 05),prostata has been reduced after therpy for 6 months( \%P\%< 0 05). Conclusion:α receptor blockade are effective in lowering blood pressure and reduce prostate that can be put into the treatment of hypertension associated with prostatic hyperplasia.