帕金森病大鼠黑质纹状体中氨基酸含量的变化

The changes of amino acid contents in nigrostriatum of hemiparkinsonian rats

目的：观察帕金森病大鼠黑质纹状体中氨基酸神经递质的变化。方法：将６－羟多巴胺（６－ＯＨＤＡ）注入鼠右侧黑质内以建立偏侧帕金森病模型，检测其黑质和纹状体中四种氨基酸的含量。结果：帕金森病大鼠损毁侧谷氨酸（Ｇｌｕ）、天门冬氨酸（Ａｓｐ）、甘氨酸（Ｇｌｙ）、和ｒ－氨丁酸（ＧＡＢＡ）的含量较未损毁侧显著增加（Ｐ＜０．０１）。结论：兴奋性氨基酸可能参与了６－ＯＨＤＡ所致的黑质纹状体内神经元损伤。

Objective: To observe the changes of amino acid contents in nigrostriatum of hemiparkinsonian rats. Methods: The model of hemiparkinsonian rats was established by right intranigral infusion of 6- hydroxydopamine (6-OHDA),the contents of four amino acids in nigral and striatum were measured respectively. Results:The levels of Glu,Asp,Gly and GABA in affected side were increased (P<0. 01). Conclusions: Excitatory amino-acids (EAA) may participate in the damage of nigrostriatum induced by 6-OHDA.