摘要
垂体腺瘤是单克隆发生的,即由基因突变引起,而侵袭性垂体腺瘤(invasive pituitary adenoma,IPA)恶性程度更高,且难治愈、易复发。对侵袭性垂体腺瘤相关原癌基因的研究有助于揭示其侵袭性,为在基因层面探索及阐明垂体腺瘤侵袭性的分子生物学机制提供新的途径和方法。全文对IPA相关原癌基因的研究进展作一综述。
Pituitary adenoma is considered to derive from monoclonal and cause by gene mutation.Invasive pituitary adenoma（IPA） possesses aggressive characteristics with reccur-prone and difficultto-cure. The research of proto-oncogene associated with IPA is helpful to reveal the significance of aggressiveness in IPA,by which the molecular biology mechanism of IPA could be clarified on the basis of gene regulation,and novel methods be provided. In this article,we summarized the research progress in proto-oncogene related IPA.
出处
《中国肿瘤》
CAS
2013年第11期897-900,共4页
China Cancer
基金
首都医科大学附属复兴医院青年科研基金(YQN201204)
关键词
垂体腺瘤
侵袭性
原癌基因
基因突变
pituitary adenoma
invasive
proto-oncogene
gene mutation
