趋化因子受体CXCR4和VEGF-C蛋白在食管癌组织中的表达及临床意义

Expressions of Chemokine Receptor CXCR4 and VEGF-C Protein in Esophageal Carcinoma and Their Significance

[目的]探讨趋化因子受体(CXCR4)和血管内皮生长因子(VEGF-C)在食管癌组织中的表达情况,及其在食管癌发生、浸润、转移中的作用。[方法]应用免疫组织化学方法检测82例食管癌组织、20例正常食管组织中CXCR4、VEGF-C表达情况,并分析其与临床病理参数的关系。[结果]CXCR4在82例食管癌组织中的阳性表达率为64.6%,CXCR4表达与食管癌患者年龄、性别无关(P>0.05),而与分化程度、病理类型、TNM分期、浸润深度和淋巴结转移有相关性(P<0.05)。VEGF-C在82例食管癌组织中的阳性表达率为74.4%,VEGF-C表达与食管癌患者年龄、性别、分化程度和病理类型无关(P>0.05),而与TNM分期、浸润深度和淋巴结转移有相关性(P<0.05)。[结论]CXCR4和VEGF-C在食管癌组织中呈高表达,且与食管癌细胞侵袭、转移和淋巴结转移相关,在促进食管癌侵袭和转移中可能存在协同作用。

[Purpose] To investigate the expressions of chemokine receptor（CXCR4）and vascular endothelial growth factor C（VEGF-C） in esophageal carcinoma tissues,and their roles in tumorigenesis,invasion and matastasis. [Methods] Immunohistochemistry was applied to detect the expression of CXCR4 and VEGF-C in 82 samples of esophageal cancer tissue and 20 samples of normal esophageal tissue. The relationship between CXCR4,VEGF-C expression and the clinicopathological features were analyzed.[Results] Positive expression rates of CXCR-4 and VEGF-C were 64.6% and74.4% respectively in esophageal cancer tissue. CXCR4 correlated to pathologic grade,histological type,clinical staging,invasion depth and lymph node metastasis（P all0.05）,but it did not correlate to gender and age（P 0.05）.VEGF-C correlated to clinical staging,invasion depth and lymph node metastasis（P all0.05）,and did not correlate to gender,age,pathologic grade and histological type（P0.05）.[Conclusion] High expression of CXCR-4 and VEGF-C exists in esophageal cancer.CXCR-4 and VEGF-C might play symergistic effect in cancer metastasis,invasion and lymph node metastasis in esophageal cancer.