“邵氏阳虚哮喘贴”防治肾阳虚型缓解期支气管哮喘多中心临床研究

“Shao's Yangxu Xiaochuan Paste”for prevention and treatment of bronchial asthma of kidney-yang deficiency type at remission stage:multi-center clinical study

目的评价“邵氏阳虚哮喘贴”穴位敷贴防治肾阳虚型缓解期支气管哮喘的临床疗效。方法采用多中心、自身前后对照方法，对144例支气管哮喘缓解期（肾阳虚证）患者，于夏季7～9月采用“邵氏阳虚哮喘贴”穴位敷贴，每周治疗2次，治疗周期为3个月，观察中医证候疗效以及中医证候积分、生活质量积分、6分钟步行试验、免疫学指标变化情况。结果144例病例经过治疗，中医证候总有效率为90．28％。治疗后，中医证候积分较治疗前下降，生活质量评分较治疗前提高，差异均有统计学意义（P〈0．05）。治疗后，6分钟步行后的呼吸困难程度较治疗前下降，步行距离较治疗前增加，差异均有统计学意义（P〈0．05）。治疗后，EOS、ECP、IgE较治疗前均有不同程度的降低（P〈0．05），CD3＋、CD8＋水平上升（P〈0．05）；其余指标差异无统计学意义（P〉0．05）。结论“邵氏阳虚哮喘贴”对肾阳虚型缓解期支气管哮喘具有较好的临床疗效。

Objective To evaluate the clinical efficacy of ＂Shao＇ s Yangxu Xiaochuan Paste＂ in preventing and treating bronchial asthma of kidney-yang deficiency type at remission stage. Methods According to multi-center and self-reflection methods, one hundred and forty-four cases were treated by aeupoint application of ＂Shao＇ s Yangxu Xiaoehuan Paste＂ from July to September, twice a week for 3 months. The scores of TCM syndrome and QOL, 6-minute walk test, immunological iodicato~ were observed. Results The total effective rate was 90.28%. After treatment, the scores of TCM syndrome, dyspnea after 6-minute walk, levels of EOS, ECP and IgE were decreased markedly （ P 〈 0.05 ）, and the scores of QOL, 6-minute walking distance, levels of CD3 ＋ and CD8 ＋ were increased markedly （P 〈 0.05 ） ; no significant difference was found in the other indicators （ P 〉 0.05 ）. Conclusion ＂Shao＇ s Yangxu Xiaochuan Paste＂ has positive effect on bronchial asthma of kidney-yang deficiency type at remission stage.