摘要
目的 评价曲唑酮治疗焦虑性神经症的疗效和副反应。方法 对 5 6例焦虑性神经症患者 ,采用曲唑酮 ( 2 8例 )地西泮 ( 2 8例 )进行对照治疗 (疗程 4周 )。采用副反应量表 (TESS)和焦虑自评量表 (SAS)、焦虑量表 (HAMD)评定疗效和副反应。结果 曲唑酮与地西泮的疗效相近 (P >0 .0 5 )。治疗第 4周末SAS、HAMA及HAMA因子分的减分率两组差异有非常显著性 (P <0 .0 1)。副反应两药相似。曲唑酮的主要副反应为困倦和嗜睡。结论 曲唑酮治疗焦虑性神经症有效 。
Objective The aim of this study was to investigate the efficiency and safety of nemonapride in the treatment of anxiety neurosis.Methods A total of 56 patients who met CCMD-2-R criteria for anxiety neurosis were randomly assigned to treatment with trazodone( n =28) or dixipan( n =28)for four weeks.The efficiency was measured with the SAS and HAMA.The adverse events were determined by the treatment emergent symptons scale(TESS).Results There was no significant difference between two groups in overall response rate showed by the reduction rate of HAMA and SAS total scores.The overall incidence and presentations of the adverse events were comparable between two groups.The most commonly observed treatment emergent adverse events of the patients with trazodone treatment were sleepy and lethargy.Conclusions It is suggested that trazodone is safe and effective in the management of anxiety neurosis.
出处
《四川精神卫生》
2000年第4期242-243,共2页
Sichuan Mental Health