痰热清注射液对呼吸机相关性肺炎高热患者C反应蛋白和感染参数的影响

Effect of Tanreqing Injection on Ventilator-associated Pneumonia Patients with High C Reactive Protein and Infections Parameters

目的:探讨痰热清注射液对呼吸机相关性肺炎高热患者C反应蛋白(CRP)和感染参数的影响。方法:选择胜利石油管理局汽修卫生院56例呼吸机相关性肺炎高热患者,按数字法随机分为对照组(n=28)和观察组(n=28),对照组采用常规治疗包括盐酸左氧氟沙星0.4 g静滴,qd,干扰素-γ,皮下注射,1次/d,12周后改隔天1次;观察组在此基础上加用痰热清注射液静滴,1个疗程用药10 d,观察两组治疗前后C反应蛋白和感染参数等指标的变化。结果:观察组与对照组临床有效率分别为92.86%(26/28),75.00%(21/28),具有统计学差异(P<0.05)。观察组治疗前CRP含量为(43.12±0.75)mg·L-1,NT-proBNP含量为(1 872.99±11.25)ng·L-1;治疗后CRP含量为(11.51±0.22)mg·L-1,NT-proBNP含量为(673.52±10.71)ng·L-1;对照组治疗前CRP含量为(44.82±0.92)mg·L-1,NT-proBNP含量为(1 863.02±11.93)ng·L-1;治疗后CRP含量为(19.64±0.84)mg·L-1,NT-proBNP含量为(894.12±10.73)ng·L-1;治疗后两组CRP均呈降低趋势,观察组降低优于对照组(P<0.05);观察组治疗后中性细胞数(GRAN)为(3.33±0.34)×109/L、白细胞(WBC)为(1.52±0.71)×109/L、淋巴细胞比率(LYM)为(51.61±7.64)%;对照组治疗后中性细胞数(GRAN)为(5.92±0.15)×109/L、白细胞(WBC)为(2.92±0.04)×10-9/L、淋巴细胞比率(LYM)(66.18±6.15)%;与治疗前比较,两组GRAN,WBC,LYM等指标均有明显降低(P<0.01),观察组降低程度显著优于对照组(P<0.05)。结论:呼吸机相关性肺炎高热患者采用痰热清静滴可以有效地抑制炎症反应,起到有效抗菌的效果。

Objective： To explore the effect of Tanreqing injection on patients with high fever of ventilator-associated pneumonia in C reactive protein（CRP） and infection parameters. Method： Fifty-six patients in our hospital of ventilator-associated pneumonia in patients with high fever,according to figures were randomly divided into control group （n=28） and observation group （n=28）,the control group with routine treatment including levofloxacin hydrochloride 0.4 g intravenous drip,QD,interferon gamma,subcutaneous injection,1 times/d,L2 weeks after the 1 day;observation group based on the use of Tanreqing injection,1 period of treatment 10 days,changes of two groups were observed before and after treatment of CRP and infection parameters. Result： The observation group and the control group clinical effective rate was 92.86% （26/28）,75% （21/28）,with significant difference （P〈0.05）. The observation group before treatment,CRP content was （43.12±0.75） mg L-1,the content of NT-proBNP is （1 872.99±11.25） ng L-1;after treatment,CRP content was （11.51±0.22） mg L-1,the content of NT-proBNP is （673.52±10.71） ng L-1;the control group before treatment,CRP content was （44.82±0.92） mg L-1,（NT-proBNP content 1 863.02±11.93） ng L-1;after treatment,CRP content was （19.64±0.84） mg L-1,the content of NT-proBNP is （894.12±10.73） ng L-1;two groups after the treatment,C reactive protein decreased,the observation group decreased than that of the control group （P〈0.05）;the observation group after treatment （GRAN） for the number of neutrophils （3.330.34）10-9/L,white blood cell （WBC） was （1.52±0.71）109/L,lymphocyte ratio （LYM） was （51.61±7.64）%;the control group after treatment （GRAN） for the number of neutrophils （5.92±0.15）109/L,white blood cell （WBC） was （2.92±0.04）109/L LYM （66.18±6.15）%;compared with before treatment,two groups of neutrophil number （GRAN）,with white blood cell （WBC）, LYM were decreased significantly （P〈0.01）,the observation group decreased significantly than that of the control group （P〈0.05）. Conclusion： Ventilator-associated pneumonia in patients with high fever by phlegm heat quiet drop can effectively inhibit the inflammatory reaction,play an effective antibacterial effect.