摘要
精原干细胞(SSCs)是精子发生过程的起源,有独特的复制方式:一次分裂可形成两个分化细胞,也可形成一个分化细胞和一个干细胞,这种自我更新和分化受到严密的调控,包括微环境、胶质细胞源性神经营养因子(GDNF)、多种信号通路等。本文综述SSCs的自我更新与分化及其调节机制,对于深入了解精子发生及男性精子发生障碍性不育、探讨睾丸肿瘤发生和寻找新的潜在治疗靶点等诸多方面有理论意义。
[ Abstract] Spermatogonial stem cells （SSCs） play an important role in spermatogenesis and have a unique mode of replication. A single SSC can produce two differentiating cells, or one stem cell and one differentiating cell. The self-renewal and differentiation of SSCs are precisely regulated as relating the niche of SSCs, glial cell line-derived neurotrophic factor, and several signaling pathways. This article reviews the self-renewal and differentiation of SSCs and their regulation mechanisms, which may offer a deeper insight into spermatogenesis and male infertility and pave a theoretical ground for studying testicular tumorigenesis and searching for new potential approaches to the treatment of testicular cancer and other related diseases. Natl J Androl, 2013, 19 （11） ： 963 -967
出处
《中华男科学杂志》
CAS
CSCD
2013年第11期963-967,共5页
National Journal of Andrology
基金
国家自然科学基金(21377052)
江苏省自然科学基金(BK20131281)~~
关键词
精原干细胞
自我更新
分化
spermatogonial stem cell
self-renewal
differentiation
