淋巴管收缩的钙调节机制

Mechanisms of calcium regulating lymphatic contraction

淋巴管系统将富含蛋白、免疫细胞以及大分子物质的组织液逆压力差从外周组织回流入血液循环,参与体液平衡、营养吸收、免疫监视等功能[1].淋巴液的运输依赖组织液的生成速率、外周组织的挤压以及淋巴管的主动周期性收缩;尤其在没有实质组织包绕的收集和运输淋巴管,其自发的周期性收缩是推动淋巴液回流的主要动力[2].淋巴管收缩功能状态在淋巴水肿[3]、休克[4]、肠道炎症[5]、代谢综合征[6]等多种疾病或病理过程的发病机制中具有重要的作用.在血液循环中,血管和心脏分别担当了通道和泵的作用;

Lymphatic system plays vital roles in fluid homeostasis, nutrition absorption and immunological surveillance, replying on the spontaneous cyclical contraction of lymphatic smooth muscle cells. The calcium ion is the key factor of various smooth muscle cell motion. Beginning with the molecular elements of lymphatic contraction, the present article reviews the mechanisms of calcium ion regulating lymphatic contraction from the aspects of pacemaker system, contractile myofilaments, calcium dependence and calcium sensitivity, thus providing a novel approach for treatment of lymphatic dysfunction disease through calaium regulation.