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内质网应激与特发性肺纤维化 被引量：3

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摘要 特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是一类病因未明、以呼吸困难症状及肺功能表现进行性恶化为特征的间质性肺疾病;病变局限于肺部,主要发生于老年患者,预后差[1]. IPF的病因及发病机制目前尚不清楚.近年来,越来越多的证据表明内质网应激（endoplasmic reticulum stress,ERS）可能在IPF的发病机制中起重要作用.现就ERS在IPF发生发展中可能发挥的作用综述如下.
作者 王艳勋 徐作军
机构地区 中国医学科学院北京协和医学院北京协和医院呼吸内科
出处 《中华医学杂志》 CAS CSCD 北大核心 2013年第44期3563-3565,共3页 National Medical Journal of China
基金 国家自然科学基金（81170055）
关键词 特发性肺纤维化 内质网应激 PULMONARY 间质性肺疾病 发病机制 IPF 呼吸困难 老年患者
分类号 R563 [医药卫生—呼吸系统]
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参考文献33

  • 1Raghu G, Collard HR, Egan JJ, et al. An Official ATS/ERS/ JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence- based guidelines for diagnosis and management. Am J Respir Crit Care Med, 2011, 183 : 788-824.
  • 2Lin JH, Walter P, Yen TS. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol, 2008, 3 : 399-.425.
  • 3SchrOder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem, 2005, 74: 739-789.
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  • 5Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol, 2003, 23 : 7448-7459.
  • 6Tanjore H, Blackwell TS, Lawson WE. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 2012, 302 : L721-L729.
  • 7Obeng EA, Boise LH. Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem, 2005, 280: 29578-29587.
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  • 9Ma Y, Brewer JW, Diehl JA, et al. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol, 2002, 318: 1351-1365.
  • 10Kuo WH, Chen JH, Lin HH, et al. Induction of apoptosis in the lung tissue from rats exposed to cigarette smoke involves p38/JNK MAPK pathway. Chem Biol Interact, 2005, 155: 31-42.

二级参考文献13

  • 1Yoshida T,Tuder RM. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev,2007,87:1047-1082.
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  • 7Harding HP,Novoa I,Zhang Y,et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells.Mol Cell,2000,6:1099-1108.
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  • 9Mast SW,Diekman K,Karaveg K,et al. Human EDEM2,a novel homolog of family 47 glycosidases, is involved in ERassociated degradation of glycoproteins.Glycobiology,2005,15:421-436.
  • 10Ruddock LW,Molinari M. N-glycan processing in ER quality control.J Cell Sci,2006,119 Pt 21:4373-4380.

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中华医学杂志
2013年 第44期

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