骨髓间充质干细胞治疗局部骨质疏松

Research progress of the treatment of regional osteoporosis with BMSCs transplantation

骨质疏松症(Osteoporosis)是一种全身性的骨代谢障碍性疾病,以骨量减少,骨微结构退化,骨脆性增加,易发生骨折为特征的全身性疾病。随着社会逐渐进入老龄化,骨质疏松症也日趋成为影响健康的主要疾病,对骨质疏松治疗方面的研究就显得更加重要了。对骨质疏松症的更进一步研究发现骨髓间充质干细胞(BMSC)的衰老也是骨质疏松的发病机制之一。骨髓间充质干细胞(BMSC)是多能的干细胞,即能够自我更新并分化成多种细胞类型,包括脂肪细胞、成骨细胞、软骨细胞。BMSC的植入能够有效增加局部骨量,提高骨密度,改善局部骨质疏松情况,可纠正骨代谢失衡,减少骨量丢失,增加成骨,为局部骨质疏松的治疗提供了一种新方法。

Osteoporosis is a systemic disorder of bone metabolism, characterized by bone loss, bone microstructure degradation, increased bone fragility, and increased risks of bone fractures. With the aging of the population, osteoporosis increasingly becomes the main disease affecting health. So the study of osteoporosis treatment becomes more important. Further research of osteoporosis reveals that the senescence of bone marrow stem cells （BMSCs） is also a possible pathogenesis of osteoporosis. BMSCs are pluripotent stem cells, which are capable of self-renewal and differentiation into various cell types, including fat cells, osteoblasts, and cartilage cells. Implantation of BMSCs can effectively increase the local bone mass, increase the bone mineral density, and improve the local situation of osteoporosis. Hence, it can correct bone metabolic imbalance, reduce bone loss, and increase osteogenesis, which can provide a new method for the treatment of regional osteoporosis.