摘要
骨质疏松及其引发的骨折高发病率已成为世界公共健康问题,探索营养物质对骨健康的有效性具有重要意义。本文综述的目的是对维生素K在人类骨健康中的防治作用进行评价分析。虽然大量观察性研究显示膳食叶绿醌(维生素K1)或MK-7与人体骨密度的提高或骨折发生率的下降有着密切关系,但干预性研究尚不能明确维生素K1或MK-4补剂对骨骼的保护作用。此外,研究资料也未证实维生素K营养状况与骨健康之间的关联性。目前相关研究资料不充分,研究方案及研究结论不一致,维生素K在人类骨健康中的有效防治作用仍存在争议。
The high prevalence of osteoporosis and the consequential fractures has become a public health problem all around the world. Therefore, it is important to explore the effectiveness of nutrients on bone health. The objective of this review is to evaluate the effect of the prevention and treatment effect of vitamin K on bone health in humans. Though several observational studies have reported an association of dietary phylloquinone or MK-7 with high bone mineral density or low risk of fractures, the intervention studies have not yet determined the protective effect of intake daily phylloquinone （vitamin K1 ） or MK-4 supplementation on bone health. In addition, the data of randomized studies have not shown the correlation between the vitamin K status and bone health. Actually, the effect of vitamin K on bone health in humans remains controversial due to the difference regarding results and/or methodologies of studies, and the insufficiency of available data.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第11期1207-1214,共8页
Chinese Journal of Osteoporosis
