妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义

Clinical value of combined determination of serum creatinine,urea nitrogen and uric acid in patients with gestational hypertension

目的探讨妊娠期高血压疾病患者血清肌酐(Cr)、尿素氮(BUN)和尿酸(UA)联合检测的临床意义。方法选择2010年1月至2012年12月本院诊治的82例妊娠期高血压疾病患者作为观察组,其中妊娠期高血压34例(A组),轻度子痫前期27例(B组),重度子痫前期21例(C组);选择同期正常妊娠孕晚期妇女作为对照组(55例)。测定血清UA、Cr和BUN三项肾功能指标水平,并比较围产儿结局。结果妊娠期高血压疾病患者血UA水平明显高于正常对照组孕妇,且随着病情发展呈现明显上升趋势,与妊娠期高血压疾病的严重程度呈正相关性,并有统计学意义(P<0.01)。血清UA值增高与胎儿生长受限、胎儿宫内窘迫、新生儿窒息及围产儿死亡的发生率呈正相关性,并有统计学意义(P<0.05)。结论妊娠期高血压疾病病情严重程度及围产儿预后与血清UA密切相关,动态联合监测UA、Cr和BUN对预测妊娠期高血压疾病病情变化和判断围产儿预后具有重要临床意义。

Objective： To study the clinical significance of combined determination of serum creatinine（Cr）,urea nitrogen（BUN）and uric acid（UA）in patients with gestational hypertension. Methods： 82 patients with gestational hypertension including 34 patients with gestational hypertension,27 patients with mild preeclampsia, 21 patients with severe preeclampsia were selected in our hospital from January 2010 to December 2012 as the observation group. 55 patients with normal latepregnant were selected as the control group. The serum levels of UA, Cr and BUN were detected. The perinatal outcomes were recorded. Results： The serum levels of UA in the patients with gestational hypertension were significantly higher than those in the control group, and increased with the development of disease. Further more, the UA levels were positive correlated with the severity of the gestational hypertension（P〈0.01）. High serum levels of UA were associated with fetal growth restriction, fetal distress in uterus, neonatal asphyxia and perinatal death（P〈0.05）. Conclusions： Serum levels of UA can reflect the severity of gestational hypertension and perinatal prognosis. It has clinical significance in predicting changes of gestational hypertension and estimating perinatal prognosis by monitoring UA levels dynamically.