银杏叶胶囊联合鼠神经生长因子辅助治疗视觉诱发电位异常眼钝挫伤

Effect of Ginkgo Biloba Combined with Mouse Nerve Growth Factor on Patients with Abnormal Visual Evoked Potentials in Eye Blunt Trauma

目的:观察银杏叶胶囊联合注射用鼠神经生长因子(mNGF)辅助治疗视觉诱发电位(VEP)异常的眼钝挫伤的临床疗效。方法:VEP异常眼钝挫伤患者40例(41眼)随机分为银杏叶组20例(21眼)和对照组20例(20眼),2组均给予基础治疗和mNGF,银杏叶组还应用银杏叶胶囊,疗程4周。观察比较两组临床疗效。结果:治疗后,银杏叶组总有效率(85.74%)优于对照组(70%),两者差异具有统计学意义(Z=-2.020,P=0.043)。治疗后2组患者视力和P100潜伏期值较治疗前都有明显改善,差异有统计学意义(P<0.05)。结论:银杏叶胶囊联合mNGF辅助治疗VEP异常的眼钝挫伤有效。

Objective： To evaluate the effect of Ginkgo biloba combined with murine nerve growth factor （mNGF） on patients with abnormal visual evoked potentials （VEP） in eye blunt trauma. Methods： Forty cases （41 eyes） with abnormal VEP in eye blunt trauma were randomly divided into Ginkgo biloba group （n： 20, 21 eyes） and Control Group （n=20, 20 eyes）. The both groups were given normal treatment and mNGF, and the Ginkgo biloba group was treated with additional Ginkgo biloba. The course of treatment was 4 weeks. The clinical efficacy was assessed. Results： The total effective rate in Ginkgo biloba Group （85.74%） was significantly better than the control group （70%） （Z=-2.020, P：0.043）. The visual acuity and P100 latency after treatment have significantly improved when compared to those before treatment in the both groups （P〈0.05）. Conclusion： Ginkgo biloba combined with mNGF was effective to treat patients with abnormal VEP in eye blunt trauma.