水飞蓟素治疗丙型肝炎疗效的Meta分析

Meta-analysis of silymarin therapy for hepatitis C

目的系统评价水飞蓟素治疗丙型病毒性肝炎的有效性。方法通过计算机检索PubMed、Medline、Embase、Cochrane图书馆、CBM、VIP、CNKI数据库。按纳入与排除标准选择随机对照实验,对纳入研究的方法学质量进行评价,提取资料。并用RevMan 5.0软件对数据进行分析。结果共纳入10篇文献,在治疗总有效率、血清丙氨酸基转移酶(ALT)方面比较治疗组均优于对照组,差异有统计学意义(P<0.001)。结论水飞蓟素对于丙型肝炎有一定的疗效,可提高总有效率,降低肝酶学指标,提高丙型肝炎患者的治愈率。

Objective To assess the efficacy of silymarin in the treatment of hepatitis C.Methods Data were retrieved from PubMed,Medline,Embase,Cochrane Library,CBM,VIP,CNKI databases.The inclusion and exclusion criteria were used to choose randomized controlled trials,the methodological quality of included studies was evaluated,The RevMan 5.0 software was used for data analysis.Results A total of 10 RCTs were included.The total effective rate,serum alanine transaminase （ALT） were better in silymarin treatment group than those in control group （P ＜0.001）.Conclusion Silymarin has certain curative effect for hepatitis C,it can increase the total effective rate,reduce liver enzyme indicators,improve the curative rate of hepatitis C.