前列素类降眼压药物的全身副作用研究进展

Research progress of the side effect of the prostaglandin drugs

青光眼是仅次于白内障的第二位致盲性眼病,降低眼压仍是目前治疗青光眼最有效的方法.前列素类药物（PG）,具有安全有效、副作用轻等特点,是目前临床治疗青光眼的一线药物.一般认为此类药物几乎无全身副作用.然而,随着临床应用的不断推广,关于PG类药物局部应用引起的全身副作用逐渐被人们所关注,包括消化系统、呼吸系统、心血管、皮肤毛发等多个组织器官的不良反应均有报道.PG类药物的全身副作用虽然少见,但应引起广大眼科医师的重视.本文对前列素类降眼压药物全身副作用的研究进展进行了综述.

Glaucoma is one of the leading causes of blindness,second to cataract.Lowering intraocular pressure is the most effective therapeutic means for this disease,with prostaglandin analogs as the first-line medication.These drugs are efficacious and safe,with well-tolerated local adverse effects.They are also generally regarded to have almost no systemic untoward effect.Nonetheless,with the continuous rise in their popularity,systemic adverse effects caused by topical ocular use of prostaglandins have attracted increasing attention.These adverse effects include digestive,respiratory,and cardiovascular systems,as well as skin and hair.Although the incidence of these adverse effects is low,physicians need to be aware of their occurrence.Research progress of the prostacyclin class IOP-lowering medication side effects are reviewed.