血清胃泌素释放肽前体在小细胞肺癌中的临床应用价值探讨

Clinical Value of Serum Pro-GRP Detection in Small Cell Lung Cancer

目的探讨血清胃泌素释放肽前体(Pro-GRP)作为小细胞肺癌(SCLC)患者的辅助诊断指标在临床应用中的价值,并与传统小细胞肺癌指标神经元特异性烯醇酶(NSE)比较。方法选择34例SCLC患者(收集于绍兴市人民医院住院病人)、49例肺部良性病变者及50例体检健康者,采用美国雅培I2000化学发光免疫测定仪测定血清Pro-GRP和NSE的值。结果小细胞肺癌患者血清中Pro-GRP和NSE浓度均高于肺部良性病变组和正常对照组,差异具有统计学意义(P<0.05);肺部良性病变组Pro-GRP的值要低于正常人对照组,差异具有统计学意义(P<0.05);Pro-GRP的ROC曲线下面积明显大于NSE线下面积(0.839 vs 0.675);Pro-GRP在SCLC广泛期组测定值明显高于局限期组(P<0.05),广泛期组阳性率明显高于NSE(80.7%vs 38.4%)。结论 Pro-GRP对小细胞肺癌诊断价值高于NSE,对小细胞肺癌是否转移具有指导价值。Pro-GRP是一个适合运用于临床小细胞肺癌高危人群筛查、鉴别诊断、分期、判断预后的肿瘤标志物。

Objective To investigate the clinical value of serum progastrin - releasing peptide（ Pro - GRP） detection in small cell lung cancer,and compare with neuron - specific enolase（NSE） detection. Methods The serum concentration of Pro - GRP and NSE in 34 cases of patients with SCLC （SCLC group） ,49 cases of patients with benign pulmonary diseases （benign disease control group）and 50 healthy cases（healthy control group）were detected by chemoluminescence immunoassay. Results The concentration of Pro - GRP and NSE in patients with SCLC was significantly higher than the patients with benign pulmonary diseases,and healthy persons and the differ- ence was statistically significant（ P 〈 0.05 ）. The concentration of Pro - GRP was lower than the healthy persons. ROC evaluation of the ar- ea under the curve of Pro - GRP and NSE were 0. 839 and 0. 675, respectively. In patients with extensive - stage, the concentration and positive rate of Pro - GRP was significantly higher than NSE（80.7% vs 38.4% ,P 〈 0.05 ）. Conclusion Pro - GRP is a tumor marker which is suitable for screening of small cell lung cancer in high - risk population, clinical differential diagnosis, staging and prognostic pre- diction.