前哨淋巴结阴性的早期乳腺癌患者两种术式的临床研究

Clinical Studies of the Negative Sentinel Lymph Node Biopsy of Early Breast Cancer and the Select the Mode of Two Operations of Breast Cancer

目的在早期乳腺癌进行前哨淋巴结活检(sentinel lymph node biopsy,SLNB),对活检阴性者采用不同的手术处理方式,并对比术后5年生存率,从而判断两种腋窝淋巴结手术处理方式对此类患者可能的预后影响。方法对55例早期乳腺癌保乳手术中前哨淋巴结活检阴性患者,随机分两组,分别行单纯前哨淋巴结活检或腋窝淋巴结清扫术(axillary lymph node dissection,ALND),并分析5年后两组患者的生存情况。结果 55例早期乳腺癌保乳手术中前哨淋巴结活检阴性患者单纯行前哨淋巴结切除或ALND 5年后患者生存率、癌肿复发转移情况无显著差异。结论在早期乳腺癌前哨淋巴结活检阴性患者行保乳手术中单纯前哨淋巴结切除是一种简便、安全的淋巴结处理方式,有望取代常规的ALND。

Objective Implement the sentinel lymph node biopsy （SLNB） during the breast - conserving surgery of the early breast cancer and adopt the different technique of the axillary lymph node （ ALN）. Finally, contrast the survival rate of the surgery five years lat- er; consequently, analyze the correlation factor which could influence the prognosis of such patients. Methods Totally 55 patients with early breast cancer were randomly divided into two groups, implement the simple sentinel lymph node biopsy （SLNB） removal and axillary lymph node dissection （ALND） respectively, and analyze the survival rate of the 2 groups five years later. Results The survival rate, metastasis and recurrence of neoplasm were not significantly different five years later. Coltclusion Simple sentinel lymph node biopsy （SLNB） removal is a convenient and safe mode of operation of the breast - conserving surgery of the early breast cancer. ALND will be re- placed by simple sentinel lymph node biopsy removal in the future.