亚洲人群中CTLA-4＋49基因多态性与Graves病遗传易感性关系的meta分析

A meta-analysis about the relation of polymorphism at the sites ＋ 49 of cytotoxic T-lymphocyte associated antigen 4 gene with the susceptibility of Graves＇ disease in Asian population

目的系统评价CTLA4＋49基因多态性在中国、日本、韩国及泰国等不同人群中与GraveS病（Graves’disease，GD）遗传易感性的定量关系。方法计算机检索PubMed、EMBASE、CNKI、万方等数据库，收集国内外关于中国、日本、韩国及泰国人群CTLA4＋49基因多态性与GD相关性的病例对照研究。采用meta分析的方法，对收集的文章进行定量综合分析。结果本次分析共纳入24篇文献，GD病例组和健康人群对照组分别为4832例和5643名。meta分析结果发现，在总人群、中国人群、日本人群的所有基因模型中（等位基因、共显性模型、显性模型、隐性模型）均发现差异有统计学意义，表明CTLA4＋49A等位基因可降低GD的发生风险。结论在亚洲人群中CTLA4＋g9G—A等位基因的突变可能为降低GD的发病风险的一个因素。

Objective To review the quantitative relationship of polymorphism at the sites ＋49 of cytotoxic T-lymphocyte associated antigen4 gene with the susceptibility of Graves＇ disease（GD） in Asian population. Methods The Medline, PubMed, Embase, Web of Science, and Chinese Biomedical Literature Database on disc （ CBM disc） databases were searched and used in recta-analysis to analyze the data in the articles collected. Results This analysis included a total of 24 papers, and GD patients and healthy population control group were composed of 4 832 cases and 5 643 subjects respectively. This paper revealed that in the general population, the Chinese people and the Japanese crowd, all the genetic models （allele, co-dominant model, dominant model, recessive model ） were statistically significant, indicating that CTLA-4 ＋49 A allele could reduce the risk of GD. Conclusions The CTLA4 ＋49 G--＊A mutation allele may serve as a factor in reducing the risk of GD susceptibility in Asian population.