摘要
目的系统评价CTLA4+49基因多态性在中国、日本、韩国及泰国等不同人群中与GraveS病(Graves’disease,GD)遗传易感性的定量关系。方法计算机检索PubMed、EMBASE、CNKI、万方等数据库,收集国内外关于中国、日本、韩国及泰国人群CTLA4+49基因多态性与GD相关性的病例对照研究。采用meta分析的方法,对收集的文章进行定量综合分析。结果本次分析共纳入24篇文献,GD病例组和健康人群对照组分别为4832例和5643名。meta分析结果发现,在总人群、中国人群、日本人群的所有基因模型中(等位基因、共显性模型、显性模型、隐性模型)均发现差异有统计学意义,表明CTLA4+49A等位基因可降低GD的发生风险。结论在亚洲人群中CTLA4+g9G—A等位基因的突变可能为降低GD的发病风险的一个因素。
Objective To review the quantitative relationship of polymorphism at the sites +49 of cytotoxic T-lymphocyte associated antigen4 gene with the susceptibility of Graves' disease(GD) in Asian population. Methods The Medline, PubMed, Embase, Web of Science, and Chinese Biomedical Literature Database on disc ( CBM disc) databases were searched and used in recta-analysis to analyze the data in the articles collected. Results This analysis included a total of 24 papers, and GD patients and healthy population control group were composed of 4 832 cases and 5 643 subjects respectively. This paper revealed that in the general population, the Chinese people and the Japanese crowd, all the genetic models (allele, co-dominant model, dominant model, recessive model ) were statistically significant, indicating that CTLA-4 +49 A allele could reduce the risk of GD. Conclusions The CTLA4 +49 G--*A mutation allele may serve as a factor in reducing the risk of GD susceptibility in Asian population.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第11期949-953,共5页
Chinese Journal of Endocrinology and Metabolism
关键词
格雷夫斯病
CTLA-4基因
多态性
META分析
Graves' disease
Cytotoxic T-lymphocyte associated antigen 4 gene
Polymorphisms
meta-analysis