纳洛酮联合依达拉奉对急性酒精中毒的临床疗效分析

Clinical Efficacy Analysis of Naloxone Combined with Edaravone on Acute Alcoholism

目的研究纳洛酮联合依达拉奉对急性酒精中毒的临床疗效分析.方法选择急性酒精中毒患者125例,随机分为对照组和治疗组.对照组采取常规治疗及纳洛酮治疗,治疗组在此基础上采用依达拉奉治疗.治疗前及经治疗后分别记录两组清醒时间、呼吸频率恢复时间及症状消失时间、检测两组患者的丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、神经元特异性烯醇化酶(NSE)、S-100β及血管细胞黏附分-1(VCAM-1).结果治疗后治疗组清醒时间及、呼吸频率恢复时间、呼吸频率恢复时间较对照组显著缩短(P<0.05).对照组治疗后S-100β对治疗前有显著性改善(P<0.05),治疗组治疗后NSE、S-100β、VCAM-1较治疗前均出现显著性下降(P<0.05),S-100β、VCAM-1较对照组差异有统计学意义(P<0.05).治疗组治疗后MDA较治疗前有显著下降且较对照组差异有统计学意义(P<0.05),SOD、GSH较治疗前有显著性升高且较对照组有显著性差异(P<0.05).结论纳洛酮及依达拉奉联合用药可以改善急性酒精中毒患者体内氧化应激状态及神经损伤,有助于该类患者早期康复.

Objective To study the clinical efficacy of naloxone combined with edaravone on acute alcoholism. Methods One hundred and twenty-five patients with acute alcoholism were randomly divided into the control and treatment groups. The control group accepted conventional treatment and taking naloxone, while the treatment group accepted edaravone on the basis. Before and after treatment,the treatment recovery time,recovery respiratory rate time and symptom disappearance time were recorded. The malondialdehyde （MDA）, superoxide dismutase （SOD）, glutathione （GSH）, neuron-specific enolase （NSE）, S-100βand vascular cell adhesion points-1 （VCAM-1） were detected. Results After treatment,the recovery time and recovery respiratory rate time of the treatment group were significantly shorter than those of the control group （ 〈0.05） . In the control group, S-100β was significantly improved after treatment （ 〈0.05） . NSE, S-100β, VCAM-1 and MDA have significantly decreased （ 〈0.05） after treatment in the treatment group. Compared with the control group, there were significant differences of S-100β,VCAM-1 and MDA in the treatment group before and after treatment （〈0.05） . While SOD and GSH have significantly increased （ 〈0.05） after treatment and showed significant differences compared with the control group （ 〈0.05） . Conclusion Naloxone and edaravone combination therapy can improve oxidative stress and nerve damage, which help early rehabilitation in patients with acute alcoholism.