摘要
抑癌基因PTEN的表达缺失多见于包括前列腺癌在内的多种散发性肿瘤,对其抑癌机制以及表达缺失所导致的肿瘤发生发展机理的研究,将为前列腺癌的诊断、治疗以及预后判断提供指导.就PTEN基因的结构、作用机制、表达缺失及其与前列腺癌发病相关的研究进展作一综述.
The deletion of tumor suppressor gene PTEN＇s expression was familiar in many tumors, including prostate cancer. The guide would be given in the diagnosis, therapy and prognosis of prostate cancer by studying about PTEN＇s tumor suppression mechanism and relation with expression deletion. This review makes an overview focusing on the recent progress of PTEN＇s structure, function, expression deletion, and the correlation between FFEN and prostate cancer.
出处
《昆明医科大学学报》
CAS
2013年第11期139-142,151,共5页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81260374/H1619)
