兔腭裂术后黏膜瘢痕生物力学性质研究

Study of biomechanical properties of mucosa scars after cleft palate surgery

目的研究兔正常腭黏膜及黏膜瘢痕的生物力学性质，及其应力与应变的关系。方法建立兔腭裂实验模型，实验组于腭黏膜瘢痕明显的部位切取宽2—3mm、长约15mm的黏膜瘢痕，对照组于相同部位切取同样大小的正常腭黏膜，于加载测试仪上做拉伸实验。结果瘢痕和正常黏膜的弹性模量分别为（24．22±1．31）MPa和（3．32±0．94）MPa，泊松比为0．49，黏膜瘢痕具有较高的弹性模量和强度，而正常黏膜的弹性模量和抗拉强度都有所下降，但瘢痕和正常黏膜的泊松比分别为（0．5±0．06）和（0．49±0．02），显示了生物活体材料的不可压缩性。结论腭裂术后黏膜瘢痕生物力学性质研究，可为临床腭裂继发上颌发育不全正颌、正畸及牵引成骨治疗提供生物力学指导。

Objective To explore biomechanical properties and stress-strain of mucosa scars after cleft palate surgery. Methods After the model of mucosa scars was made, the mucosa scars and normal mucosa were excised and examined immediately by tensionometry. Results The mucosa scars after cleft palate surgery were compared with normal mucosa. The Poisson＇ s ratio of mucosa scars and normal mucosa was 0. 5 and 0. 49, respectively, showing no significant difference between the two groups. The ultimate Young＇ s modulus of mucosa scars was about 24.22 MPa, however, it declined to 3.32 Mpa in normal mucosa. Conclusions The mucosa scars after cleft palate surgery are biomechanically weaker than normal mucosa. It can be used for further research, such as maxillary orthognathic surgery, distraction osteogenesis, and orthodontic treatment.