MoCA和MMSE在皮质下缺血性血管性疾病早期诊断中的应用价值

The application value of MoCA and MMSE in the early diagnosis of subcortical ischemic vascular disease

目的:对比蒙特利尔认知评估量表(MoCA)和简易精神状态量表(MMSE)对皮质下缺血性血管性疾病(SIVD)的诊断价值。方法:98例轻度认知功能损害(vMCI)患者中行MoCA检查50例(MoCA-M组),行MMSE检查48例(MMSE-M组)。对照组85例中行MoCA检查46例(MoCA-C组),行MMSE检查39例(MMSE-C组)。结果:对vMCI患者检查的灵敏度,MoCA(78.0%)显著高于MMSE(52.1%)(P<0.01)。MoCA特异度的(71.7%)高于MMSE(48.7%)(P<0.05)。结论:MoCA对检出vMCI有更高的敏感度和特异度,有望成为临床上对SIVD早期阶段筛选的快捷有效的手段。

Objective： To compare the diagnostic value of MoCA and MMSE in subcortical ischemic vascular disease （SIVD）. Methods： In 98 cases with vascular cognitive impairment （ vMCI）, 50 cases （ MoCA-M group） and 48 cases （ MMSE-M group） were measuured by MoCA and MMSE, respectively. In 85 control cases, 46 cases （ MoCA-C group） and 39 cases （ MMSE-C group） were measured by MoCA and MMSE, respectively. Results ： The sensitivity of MoCA-M group （78. 0% ） in patients with vMCI was significantly higher than that of MMSE-M group （52.1%） （ P 〈 0.01 ）. The specificity of MoCA-M group （71.7%） in patients with vMCI was higher than that of MMSE-M group （48.7%）（ P 〈 0.05 ）. Conclusions： MoCA has high sensitivity and specificity for detecting vMCI,which may become a effective way for the early diagnosis of SIVD in clinic.