降钙素原在细菌感染性疾病中的诊断作用

Role of procalcitonin in diagnosis of bacterial infection

目的:探讨血清降钙素原(PCT)在细菌感染性疾病中的诊断价值。方法:回顾性分析36例细菌培养阳性和40例细菌培养阴性住院患者的PCT、血白细胞(WBC)计数和C反应蛋白(CRP)检测结果,PCT检测采用半定量免疫色谱法。结果:2组PCT分级差异无统计学意义(P>0.05)。细菌培养阳性组WBC和CRP均明显高于细菌培养阴性组(P<0.01)。细菌培养阳性组PCT、WBC、CRP阳性率依次为36.11%、63.89%、97.22%,细菌培养阴性组PCT、WBC、CRP阳性率依次为25.00%、22.50%、72.50%,细菌培养阳性组WBC、CRP阳性率均明显高于细菌培养阴性组(P<0.01),2组PCT阳性率差异无统计学意义(P>0.05)。灵敏度依次为PCT 36.11%、WBC 63.89%、CRP 97.22%,特异度依次为PCT 75.00%、WBC 77.50%、CRP27.50%。结论:PCT在细菌感染诊断中有一定价值,与WBC和CRP联合检测能够更准确地判断细菌感染。

Objective： To investigate the value of serum procalcitonin （PCT） in the diagnosis of bacterial infection. Methods：The results of PCT, white blood cell （WBC） and C reactive protein （CRP） in 36 cases with positive bacterial culture and 40 cases with negative bacterial culture were analyzed retrospectively. The PCT was detected by semi-quantitative immunochromatography. Results： There was no statistical difference in the grading of PCT between the two groups（P 〉 0.05 ）. The mean WBC and CRP in the positive bacterial culture group were significantly higher than those in the negative bacterial culture group（ P 〈 0.01 ）. The positive rate of PCT, WBC and CRP was 36.11% ,63.89% and 97.22% respectively in the positive bacterial culture group, and 25.00% ,22.50% and 72.50% respectively in the negative bacterial culture group. The positive rate of WBC and CRP in the positive bacterial culture group was apparently higher than that in the negative bacterial culture group（ P 〈 0.01 ）. There was no statistical difference in the positive rate of PCT between the two groups （P 〉 0.05 ）. The sensitivity of PCT was 36.11%, WBC 63.89% and CRP 97.22% ; the specificity of PCT was 75.00% ,WBC 77.50% and CRP 27.50%, respectively. Conclusions： Serum PCT is of value in diagnosis of bacterial infection. Combined determination of PCT, WBC and CRP may help to make accurate diagnosis of bacterial infection.