摘要
目的:探讨根治性放疗后短期复发食管癌的合理治疗。方法:回顾性分析21例食管癌放疗后短期复发患者(手术组)的手术情况,并与22例接受保守性治疗的患者(保守治疗组)进行比较。结果:手术组有20例(95.2%)完成了肿瘤切除,术后发生低氧血症15例,肺部感染2例,吻合口瘘1例。手术组术后1、3、5年生存率分别为71.4%、33.3%和14.3%。保守治疗组术后1年生存率为45.5%,与手术组比较差异无统计学意义(P〉0.05);保守治疗组2年后无生存者,生存期2~17个月。肿瘤复发治疗后半年疗效满意度手术组为66.7%,明显高于保守治疗组的27.3%(P〈0.01)。结论:根治性放疗后短期复发食管癌的手术风险较大,手术难度增加,须仔细行围手术期准备,手术能给患者带来生存受益。
Objective: To explore a rational therapy for recurrent esophageal carcinoma after radical radiotherapy. Methods:The clinical data of 21 patients with esophageal carcinoma having received esophagectomy were analyzed and compared with those of 22 patients treated by conservative therapy. Results:Twenty cases in the surgery group(95.2% ) underwent esophagectomy. Postoperative hyoxemia occurred in 15 cases, anastomotic leakage in 1 case and pulmonary infection in 2 cases. The 1,3 and 5-year survival rate was 71.4% ,33.3% and 14.3% respectively in the surgery group,while the 1-year survival rate was 45.5% in the conservative treatment group, the difference was not significant (P 〉 0.05 ), no one in the conservative treatment group survived after 2 years, and their survival duration was 2 - 17 months. The satisfaction degree half-year after the recurrence was 66.7% in the surgery group, which was significantly higher than the 27.3% in the conservative treatment group( P 〈 0.01 ). Conclusions:Surgery is of great risk for patients with recurrent esophageal carcinoma after curative radiotherapy, so attentive peril-operation preparation is essential. Operation may bring survival benefit to those patients.
出处
《蚌埠医学院学报》
CAS
2013年第11期1438-1440,共3页
Journal of Bengbu Medical College
关键词
食管肿瘤
复发
放射治疗
手术治疗
预后
esophageal neoplasms
recurrence
radiation therapy
the surgical treatment
prognosis