摘要
目的探讨早期乳腺癌保乳术后行调强放疗的近期疗效。方法回顾性分析2007年1月-2009年1月收治的55例保乳治疗后行放疗的早期乳腺癌患者的临床资料,其中28例(50.9%)行调强放疗,27例(49.1%)行常规放疗,两组照射剂量均为全乳腺照射50 Gy/25次,瘤床补量10 Gy/5次,观察临床毒性反应、疗效及美容效果。结果调强放疗组中发生1级急性放射性皮肤反应26例,2级2例,而常规放疗组中分别为19例、8例,调强放疗组较常规放疗组,降低了2级急性放射性皮肤反应的发生率(7.1%vs 29.6%,P<0.05),两组均未发现3、4级急性放射性皮肤反应及乳腺纤维化,两组3年局部控制率、无瘤生存率及远处转移率差异均无统计学意义;随访3年,调强放疗组美容评分均在3分以上,优良率100%,常规放疗组中1例患者出现双侧乳腺对称性差,评分2分,其余26例评分在3分以上,两组患者随访至今未发现明显的放射性心脏、肺毒性。结论早期乳腺癌保乳术后调强放疗降低了2级急性皮肤反应发生率,3年随访,肿瘤局部控制率、无瘤生存率及远处转移率与常规放疗组相比差异无统计学意义,乳腺毒副反应轻,美容效果好,提高了患者的生活质量。
Objective To study the short-term outcome of intensity-modulated radiation therapy(IMRT) for early stage breast cancer after breast-conserving surgery. Methods The clinical data of 55 patients with early stage breast cancer undergoing the radiotherapy after breast-conserving surgery from January 2007 to January 2009 were retrospectively reviewed. Of the 55 patients, 28 cases (50.9%) were treated with IMRT, and the 27 patients (49.1% ) with conventional radiation therapy (cRT). All patients received whole breast radiation(WBI) ( median dose ,50Gy/25f) followed by a boost to 60 Gy. The median follow-up was 3 years. The skin toxicity,cosmetic effect and clinical outcomes were observed and analyzed. Results Grade 1 of acute radiation skin re- action was seen in 26 patients and grade 2 in 2 patients of patients with IMRT,accordingly, 19 patients and 8 patients were seen in team with cRT. There was not more than grade 2 of skin reaction for all the patients. Treatment with IMRT decreased acute skin toxicity of Radiation Therapy Oncology Group Grade 1 or 2 compared with cRT( 7.1% vs. 29.6% ; P 〈 0.05 ). Comparing IMRT with cRT, there were no statistically significant differences in local control raterate at 1 st year,2nd and 3rd year, disease-free sur- vival at 3rd year, and distant metastasis, or second malignancies. Excellent or good cosmetic outcome was 100% at 3rd year in IM- RT group, and one patient was with 2 scores for bad symmetrical characteristic in cRT group, and others were excellent or good in the group. The toxicity of heart and lung was not observed during the follow- up period for all the patients. Conclusion The inci- dence of acute skin toxicity can be decreased by IMRT in patients with early stage breast cancer after breast-conserving surgery. The local control rate in cancer,disease-free survival and distant metastasis rate are similar to the cRT group. The side effects is light, the cosmetic outcome is satisfactory. The life quality of patients can be improved.
出处
《中华全科医学》
2013年第12期1855-1857,共3页
Chinese Journal of General Practice
关键词
乳腺癌
保乳术
放射治疗
Breast cancer
Breast-conserving surgery
Radiotherapy